ABSTRACT

Aging is associated with a number of alterations to cerebrovascular function. We aimed to investigate the effect of age on cerebrovascular responses to cognitive stimulation using an objective two-parameter method.

Previously derived from a large data-set (135 healthy participants) were applied to a task-activated dataset of 69 healthy participants in five different task conditions. Cumulative response rate (CRR) was calculated as the sum of responses across tasks and hemispheres.

There was a significant effect of age (adjusted odds ratio: 1.02 (95% confidence interval: 1.01, 1.04), p = 0.016). There was also a significant effect of task (p = 0.002), but there was no significant interaction between age and task (p = 0.37). Increasing age was associated with increased CRR (adjusted odds ratio: 1.04 (95% confidence interval: 1.01, 1.07), p = 0.009).

Using an objective two-parameter method, healthy older adults had increased cerebrovascular responses to cognitive testing.

摘要

衰老与脑血管功能的许多改变有关。我们旨在使用客观的两参数方法研究年龄对认知刺激的脑血管反应的影响。

之前从一个大型数据集（135 名健康参与者）中获得的数据被应用于一个由 69 名健康参与者在五种不同任务条件下组成的任务激活数据集。累积响应率 (CRR) 计算为跨任务和半球响应的总和。

年龄有显着影响（调整优势比：1.02（95% 置信区间：1.01, 1.04），p = 0.016）。任务也有显着影响（p = 0.002），但年龄和任务之间没有显着的交互作用（p = 0.37）。年龄增加与 CRR 增加相关（调整优势比：1.04（95% 置信区间：1.01, 1.07），p = 0.009）。

使用客观的两参数方法，健康老年人对认知测试的脑血管反应增加。