Background

Indications for a minimally invasive resections are increasing worldwide, but respecting anatomical planes during intraparenchymal transection is demanding. Intraoperative ICG fluorescence staining of liver parenchyma has been introduced as a tool for real-time intraoperative guidance. The aim of this study is to make a systematic review of the current relevant literature on indications, techniques, and results of laparoscopic anatomical liver resection (LALR) using intraoperative indocyanine green (ICG) fluorescence for positive and negative staining of liver segments in patients affected by liver malignancies.

Methods

Electronic bibliographical databases (MEDLINE and PubMed) were searched according to the PRISMA criteria. English language articles meeting the selection criteria and published until June 2020 were retrieved and reviewed.

Results

a total of 86 articles were initially found and 11 articles were finally included in the analysis with a total of 83 patients treated. Sixty-two patients (74.6%) underwent mono-segmentectomies. Thirty-five patients (42.1%) underwent the positive staining technique, and forty-eight patients (57.8%) the negative staining technique.

Conclusions

The positive or negative indocyanine green staining technique with real-time fluorescence guidance is an emerging and promising approach. However, the technique has to be standardized and advantages in terms of oncologic results still need validation in further studies.

中文翻译：

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腹腔镜解剖性肝切除术使用阳性或阴性染色技术与术中吲哚菁绿荧光成像

背景

微创切除的适应症在全球范围内不断增加，但在实质内横断期间尊重解剖平面是一项艰巨的任务。肝实质的术中 ICG 荧光染色已被引入作为实时术中指导的工具。本研究的目的是对当前有关使用术中吲哚菁绿 (ICG) 荧光对受影响患者的肝段进行阳性和阴性染色的腹腔镜解剖性肝切除术 (LALR) 的适应症、技术和结果的相关文献进行系统评价通过肝脏恶性肿瘤。

方法

根据 PRISMA 标准搜索电子书目数据库（MEDLINE 和 PubMed）。检索和审查了符合选择标准并发表至 2020 年 6 月的英语文章。

结果

最初共找到86篇文章，最终纳入分析11篇，共治疗83名患者。62 名患者 (74.6%) 接受了单节段切除术。35名患者（42.1%）接受了阳性染色技术，48名患者（57.8%）接受了阴性染色技术。

结论

具有实时荧光引导的阳性或阴性吲哚菁绿染色技术是一种新兴且有前途的方法。然而，该技术必须标准化，并且在肿瘤学结果方面的优势仍需要在进一步的研究中验证。