Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour cells and bacteria/virus-infected cells. However, comprehensive studies conducted on GZMB have gradually revealed the negative extracellular functions of GZMB; for example, it is an aetiology and a factor responsible for the aggravation of several diseases. This review focuses on the positive role of GZMB (in the elimination of tumour cells, bacteria, parasites and viruses, and in the identification, diagnosis and treatment of diseases) and the negative effects of GZMB (with regard to extracellular function and other characteristics). The current research on GZMB inhibitors has been briefly introduced, and few studies on GZMB fusion proteins and several GZMB material delivery systems have been discussed.

中文翻译：

---

颗粒酶 B 的双重作用

颗粒酶 B (GZMB) 最初被确定为一种可以消除肿瘤细胞和细菌/病毒感染细胞等细胞的因子。然而，对GZMB进行的综合研究逐渐揭示了GZMB的负面细胞外功能；例如，它是导致多种疾病恶化的病因和因素。本综述重点讨论了 GZMB（在消除肿瘤细胞、细菌、寄生虫和病毒，以及在疾病的识别、诊断和治疗中）的积极作用和 GZMB 的负面影响（关于细胞外功能和其他特性） . 简要介绍了目前对 GZMB 抑制剂的研究，很少讨论 GZMB 融合蛋白和几种 GZMB 物质传递系统的研究。