Attentional lapses interfere with goal-directed behaviors, which may result in harmless (e.g., not hearing instructions) or severe (e.g., fatal car accident) consequences. Task-related functional MRI (fMRI) studies have shown a link between attentional lapses and activity in the frontoparietal network. Activity in this network is likely to be mediated by the organization of the white matter fiber pathways that connect the regions implicated in the network, such as the superior longitudinal fasciculus I (SLF-I). In the present study, we investigate the relationship between susceptibility to attentional lapses and relevant white matter pathways in 36 healthy adults (23 females, M_age = 31.56 years). Participants underwent a diffusion MRI (dMRI) scan and completed the global–local task to measure attentional lapses, similar to previous fMRI studies. Applying the fixel-based analysis framework for fiber-specific analysis of dMRI data, we investigated the association between attentional lapses and variability in microstructural fiber density (FD) and macrostructural (morphological) fiber-bundle cross section (FC) in the SLF-I. Our results revealed a significant negative association between higher total number of attentional lapses and lower FD in the left SLF-I. This finding indicates that the variation in the microstructure of a key frontoparietal white matter tract is associated with attentional lapses and may provide a trait-like biomarker in the general population. However, SLF-I microstructure alone does not explain propensity for attentional lapses, as other factors such as sleep deprivation or underlying psychological conditions (e.g., sleep disorders) may also lead to higher susceptibility in both healthy people and those with neurological disorders.

中文翻译：

---

注意失误的个体差异与健康成年人的纤维特异性白质微结构有关

注意失误会干扰目标导向的行为，这可能导致无害（例如，听不到指令）或严重（例如，致命的车祸）后果。与任务相关的功能磁共振成像 (fMRI) 研究表明，注意力缺失与额顶网络活动之间存在联系。该网络中的活动可能由连接网络中涉及的区域的白质纤维通路的组织介导，例如上纵束 I (SLF-I)。在本研究中，我们调查了 36 名健康成年人（23 名女性，M_岁 = 31.56 年）。参与者接受了扩散 MRI (dMRI) 扫描，并完成了测量注意力失误的全局-局部任务，类似于之前的 fMRI 研究。将基于固定点的分析框架应用于特定光纤通过对 dMRI 数据的分析，我们研究了 SLF-I 中的注意力失误与微观结构纤维密度 (FD) 和宏观结构（形态）纤维束横截面 (FC) 的变异性之间的关联。我们的结果显示，左侧 SLF-I 中较高的注意力失误总数与较低的 FD 之间存在显着的负相关。这一发现表明，关键额顶叶白质束微观结构的变化与注意力缺失有关，并可能在一般人群中提供类似特征的生物标志物。然而，仅 SLF-I 微观结构并不能解释注意力缺失的倾向，因为其他因素如睡眠剥夺或潜在的心理状况（例如，