Orthopedic implant is commonly associated with occurrence or relapse of osteomyelitis. This study developed a hydrofluoric acid (HF) cleaned silicon nitride (Si₃N₄) implant Si₃N₄_AC for osteomyelitis control and established a rat tibial osteomyelitis model to evaluate its efficacy on eradicating periprosthetic infection and enhancing bone regeneration. In vitro studies revealed Si₃N₄_AC had improved biocompatibility and inhibited Staphylococcus aureus adhesion. A custom-made Si₃N₄_AC implant was prepared and inserted into the rat tibia longitudinal cavity inoculated with Staphylococcus aureus. The in vivo bacteriostatic and osteogenic efficacies of Si₃N₄_AC implant were evaluated by histological, microbiological and Micro-CT analyses and compared with implants of pure Ti and Si₃N₄ . Si₃N₄_AC implant group revealed 99.5% inhibition of periprosthetic Staphylococcus aureus compared to the osteomyelitis group after 14 days post-operation. Implant-adhering bacteria density of Si₃N₄_AC was also much lower than pure Ti and Si₃N₄. In addition, micro-CT evaluation of peri-implant bone formation under the condition of periprosthetic osteomyelitis after 30 days post-surgery confirmed the osteogenic ability of Si₃N₄_AC. Taken together, Si₃N₄_AC can be an effective orthopedic biomaterial to eradicate periprosthetic infection and enhance bone regeneration.

骨科植入物通常与骨髓炎的发生或复发有关。本研究开发了一种用于骨髓炎控制的氢氟酸 (HF) 清洁氮化硅 (Si ₃ N ₄ ) 植入物 Si ₃ N ₄ _AC，并建立了大鼠胫骨骨髓炎模型，以评估其根除假体周围感染和促进骨再生的功效。体外研究表明，Si ₃ N ₄ _AC 具有改善的生物相容性并抑制金黄色葡萄球菌的粘附。制备了定制的 Si ₃ N ₄ _AC 植入物并将其插入接种了金黄色葡萄球菌。在体内的Si的抑菌和成骨功效₃ Ñ ₄ _AC植入物通过组织学，微生物学和微CT分析评估，并与纯的Ti和Si的植入物相比，₃ Ñ ₄。与骨髓炎组相比，Si ₃ N ₄ _AC 种植体组在术后 14 天显示出对假体周围金黄色葡萄球菌的抑制率为 99.5% 。Si ₃ N ₄ _AC的植入物粘附细菌密度也远低于纯Ti和Si ₃ N ₄. 此外，术后30天假体周围骨髓炎条件下种植体周围骨形成的显微​​CT评估证实了Si ₃ N ₄ _AC的成骨能力。总之，Si ₃ N ₄ _AC 是一种有效的骨科生物材料，可以根除假体周围感染并促进骨再生。