Objectives. Previous researches have demonstrated that abnormal functional connectivity (FC) is associated with the pathophysiology of bipolar disorder (BD). However, inconsistent results were obtained due to different selections of regions of interest in previous researches. This study is aimed at examining voxel-wise brain-wide functional connectivity (FC) alterations in the first-episode, drug-naive patient with BD in an unbiased way. Methods. A total of 35 patients with BD and 37 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI). Global-brain FC (GFC) was applied to analyze the image data. Support vector machine (SVM) was adopted to probe whether GFC abnormalities could be used to identify the patients from the controls. Results. Patients with BD exhibited increased GFC in the left inferior frontal gyrus (LIFG), pars triangularis and left precuneus (PCu)/superior occipital gyrus (SOG). The left PCu belongs to the default mode network (DMN). Furthermore, increased GFC in the LIFG, pars triangularis was positively correlated with the triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) and negatively correlated with the scores of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) coding test and Stroop color. Increased GFC values in the left PCu/SOG can be applied to discriminate patients from controls with preferable sensitivity (80.00%), specificity (75.68%), and accuracy (77.78%). Conclusions. This study found increased GFC in the brain regions of DMN; LIFG, pars triangularis; and LSOG, which was associated with dyslipidemia and cognitive impairment in patients with BD. Moreover, increased GFC values in the left PCu/SOG may be utilized as a potential biomarker to differentiate patients with BD from controls.

中文翻译：

---

全球大脑功能连接的增加与首发、未用药的双相情感障碍患者的血脂异常和认知障碍有关

目标。先前的研究表明，异常的功能连接（FC）与双相情感障碍（BD）的病理生理学有关。然而，由于先前研究中对感兴趣区域的选择不同，得到了不一致的结果。本研究旨在以公正的方式检查首发未用药的 BD 患者的体素全脑功能连接 (FC) 变化。方法。共有 35 名 BD 患者和 37 名年龄、性别和教育程度匹配的健康对照者接受了静息状态功能磁共振成像 (rs-fMRI)。应用全局脑 FC (GFC) 来分析图像数据。采用支持向量机（SVM）来探讨是否可以使用 GFC 异常来识别对照中的患者。结果。BD 患者的左额下回 (LIFG)、三角肌和左楔前叶 (PCu)/枕上回 (SOG) 的 GFC 增加。左侧 PCu 属于默认模式网络 (DMN)。此外，LIFG 中 GFC 的增加，三角肌与甘油三酯 (TG) 和低密度脂蛋白胆固醇 (LDL-C) 呈正相关，与用于评估神经心理状态的可重复电池 (RBANS) 编码的分数呈负相关测试和 Stroop 颜色。左侧 PCu/SOG 中增加的 GFC 值可用于区分患者与对照组，具有较好的敏感性 (80.00%)、特异性 (75.68%) 和准确度 (77.78%)。结论. 这项研究发现 DMN 大脑区域的 GFC 增加；LIFG，三角部；和 LSOG，这与 BD 患者的血脂异常和认知障碍有关。此外，左侧 PCu/SOG 中增加的 GFC 值可用作区分 BD 患者与对照组的潜在生物标志物。