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Silanized graphene oxide as a reinforcing agent for acrylic bone cements: physicochemical, mechanical and biological characterization
Journal of Biomaterials Science, Polymer Edition ( IF 3.6 ) Pub Date : 2021-06-21 , DOI: 10.1080/09205063.2021.1937464
Baptiste Levenez 1 , Tania Gil-Cortes 2 , Nayeli Rodríguez-Fuentes 3 , Juana Enríquez Jiménez 4 , Wilberth Herrera-Kao 2 , María I Loría-Bastarrachea 2 , Alejandro May-Pat 2 , Cynthia Guerrero-Bermea 2 , Jorge Uribe-Calderón 2 , José M Cervantes-Uc 2
Affiliation  

Abstract

Recently, different carbon-based nanomaterials have been used as reinforcing agents in acrylic bone cement formulations. Among them, graphene oxide (GO) has attracted the attention of scientific community since it could improve not only the mechanical properties but also the biocompatibility characteristics of these materials. However, using GO presents some drawbacks, such as its poor dispersion and lack of interaction with polymeric matrices, which should be prior resolved to achieve its optimal performance in acrylic bone cement. Thus, in this work, GO was treated with 3-methacryloxy propyl trimethoxy silane at various concentrations (1, 3 and 5 wt.%) to improve the interaction between the nanofiller and the poly (methyl methacrylate) matrix. Modified GO was incorporated at different percentages (0.1, 0.5 and 0.75 wt.%) into acrylic bone cement formulations and some properties were evaluated. The silanization process of the GO was confirmed by FTIR, TGA and EDX. The improvement in the mechanical performance was monitored on the compression properties whereas those related with biological properties were evaluated by osteoblast cell viability and hemocompatibility tests. Results suggest that using a 1 wt.% of the silane coupling agent, during surface treatment of GO, yields the best mechanical performance in this type of materials. It was also found that the presence of neat GO or silanized GO does not compromise the cytocompatibility and hemocompatibility of acrylic bone cement formulations.



中文翻译:

硅烷化氧化石墨烯作为丙烯酸骨水泥的增强剂:物理化学、机械和生物表征

摘要

最近,不同的碳基纳米材料已被用作丙烯酸骨水泥配方中的增强剂。其中,氧化石墨烯(GO)不仅可以提高这些材料的机械性能,还可以提高其生物相容性,因此引起了科学界的关注。然而,使用 GO 存在一些缺点,例如其分散性差和与聚合物基质缺乏相互作用,应事先解决这些问题,以实现其在丙烯酸骨水泥中的最佳性能。因此,在这项工作中,GO 用不同浓度(1、3 和 5 重量%)的 3-甲基丙烯酰氧基丙基三甲氧基硅烷处理,以改善纳米填料和聚(甲基丙烯酸甲酯)基质之间的相互作用。改性 GO 以不同的百分比(0.1、0.5 和 0.75 wt. %) 到丙烯酸骨水泥配方中,并评估了一些性能。通过 FTIR、TGA 和 EDX 证实了 GO 的硅烷化过程。机械性能的改善通过压缩特性进行监测,而与生物特性相关的则通过成骨细胞活力和血液相容性测试进行评估。结果表明,在 GO 表面处理过程中,使用 1 wt.% 的硅烷偶联剂可在此类材料中获得最佳机械性能。还发现纯 GO 或硅烷化 GO 的存在不会损害丙烯酸骨水泥制剂的细胞相容性和血液相容性。机械性能的改善通过压缩特性进行监测,而与生物特性相关的则通过成骨细胞活力和血液相容性测试进行评估。结果表明,在 GO 表面处理过程中,使用 1 wt.% 的硅烷偶联剂可在此类材料中获得最佳机械性能。还发现纯 GO 或硅烷化 GO 的存在不会损害丙烯酸骨水泥制剂的细胞相容性和血液相容性。机械性能的改善通过压缩特性进行监测,而与生物特性相关的则通过成骨细胞活力和血液相容性测试进行评估。结果表明,在 GO 表面处理过程中,使用 1 wt.% 的硅烷偶联剂可在此类材料中获得最佳机械性能。还发现纯 GO 或硅烷化 GO 的存在不会损害丙烯酸骨水泥制剂的细胞相容性和血液相容性。在此类材料中产生最佳机械性能。还发现纯 GO 或硅烷化 GO 的存在不会损害丙烯酸骨水泥制剂的细胞相容性和血液相容性。在此类材料中产生最佳机械性能。还发现纯 GO 或硅烷化 GO 的存在不会损害丙烯酸骨水泥制剂的细胞相容性和血液相容性。

更新日期:2021-06-21
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