Not all human naïve CD4⁺ T cells are created equal

It has long been thought that naïve CD4⁺ T cells are a homogeneous population all with the same potential to contribute different specialized skills to eliminate infected and abnormal cells. However, recent studies in mice suggest this is not the case; it is becoming increasingly clear that naïve T cells vary in pre-existing biases for certain skills prior to their deployment during an immune response. In this issue, Sood and Lebel et al. now show that different cell surface levels of CD5 appear to mark human naïve CD4⁺ T cells with distinct gene expression profiles at steady state, as well as differences in the strength with which they interact with foreign antigen and the cytokines they produce after activation. Establishing CD5 as a reliable marker of functional heterogeneity in human naïve T cells sets a foundation for developing tools to isolate human T cells with specific characteristics to improve the effectiveness of cell therapies.

中文翻译：

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期刊综述

并非所有人类幼稚的 CD4 ⁺ T 细胞都生而平等

长期以来，人们一直认为幼稚 CD4 ⁺ T 细胞是同质群体，它们都具有相同的潜力，可以贡献不同的专业技能来消除受感染和异常细胞。然而，最近对小鼠的研究表明情况并非如此。越来越清楚的是，幼稚 T 细胞在免疫反应期间部署之前，对某些技能的预先存在的偏见会有所不同。在这个问题上，Sood 和 Lebel 等人。现在表明不同细胞表面水平的 CD5 似乎标志着人类幼稚的 CD4 ⁺在稳定状态下具有不同基因表达谱的 T 细胞，以及它们与外源抗原相互作用的强度以及它们在激活后产生的细胞因子的差异。将 CD5 确立为人类幼稚 T 细胞功能异质性的可靠标志物，为开发工具以分离具有特定特征的人类 T 细胞以提高细胞疗法的有效性奠定了基础。