Background Information avoidance tendencies have been found to be associated with lower intentions to pursue medically actionable genomic sequencing results, but less so among individuals who engage more in spontaneous self-affirmation. Yet these results were obtained with a largely non-Hispanic White, high-SES cohort. Purpose To assess these variables, their magnitude, and their associations in an African-descent cohort as part of the same ClinSeq® exome sequencing program. Methods Participants reported levels of spontaneous self-affirmation, information avoidance, and intentions to receive three types of results – medically actionable, non-medically actionable, and carrier status as part of a baseline survey. Results Relative to the original, non-Hispanic White cohort, those in the African-descent cohort had higher levels of spontaneous self-affirmation and lower intentions of learning about carrier genomic results; they reported comparable levels of information avoidance and intentions to receive other results. Information avoidance was negatively associated with intention to receive non-actionable results in the African-descent cohort, as found in the initial cohort, with no moderating effect of spontaneous self-affirmation. Information avoidance, spontaneous self-affirmation, and their interaction were not associated with intentions to receive actionable results (contrary to findings in the initial cohort), or carrier results. Conclusions Individuals of African descent may engage in relatively more spontaneous self-affirmation, and do not appear to engage in more information avoidance. Their information avoidance tendencies were associated with pursuit of non-actionable sequencing results, with no moderating effect of self-affirmation, and were not associated with pursuit of actionable results or carrier results.

中文翻译：

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非洲人后裔队列成员的信息回避、自我肯定和接收基因组测序结果的意图

背景信息回避倾向已被发现与追求医学上可行的基因组测序结果的意愿较低有关，但在更多地参与自发自我肯定的个体中则较少。然而，这些结果是在一个主要是非西班牙裔白人、高 SES 的队列中获得的。目的 作为同一 ClinSeq® 外显子组测序计划的一部分，在非洲裔队列中评估这些变量、它们的大小和它们之间的关联。方法 作为基线调查的一部分，参与者报告了自发的自我肯定、信息回避和接收三种类型结果的意图——医学上可行的、非医学上可行的和携带者状态。结果 相对于原始的非西班牙裔白人队列，非洲裔队列中的人自发的自我肯定程度较高，而了解携带者基因组结果的意愿较低；他们报告了相当程度的信息回避和获得其他结果的意图。正如在最初的队列中发现的那样，在非洲裔队列中，信息回避与接受不可操作结果的意图呈负相关，而自发的自我肯定没有调节作用。信息回避、自发的自我肯定以及它们之间的相互作用与接收可操作结果的意图（与初始队列中的发现相反）或携带者结果无关。结论 非洲人后裔的个体可能会进行相对更自发的自我肯定，并且似乎不会进行更多的信息回避。