Smokeless tobacco products possess a complex community of microorganisms. The microbial community ferment compounds present in the smokeless tobacco products and convert them into carcinogens like tobacco-associated nitrosamines. However, the potential of smokeless tobacco products associated bacteriome to manipulate systemic inflammation and other signaling pathways involved in the etiology of oral cancer will be a risk factor for oral cancer. Further, damage to oral epithelial cells causes a leaky oral layer that leads to increased infiltration of bacterial components like lipopolysaccharide, flagellin, and toxins, etc. The consumption of smokeless tobacco products can cause damage to the oral layer and dysbiosis of oral microbiota. Hence, the enrichment of harmful microbes due to dysbiosis in the oral cavity can produce high levels of bacterial metabolites and provoke inflammation as well as carcinogenesis. Understanding the complex and dynamic interrelation between the smokeless tobacco-linked bacteriome and host oral microbiome may help to unravel the mechanism of oral carcinogenesis stimulated by smokeless tobacco products. This review provides an insight into smokeless tobacco product-associated bacteriome and their potential in the progression of oral cancer. In the future, this will guide in the evolution of prevention and treatment strategies against smokeless tobacco products-induced oral cancer. Besides, it will assist the government organizations for better management and cessation policy building for the worldwide problem of smokeless tobacco addiction.

无烟烟草制品具有复杂的微生物群落。微生物群落发酵无烟烟草产品中存在的化合物，并将其转化为致癌物质，如烟草相关亚硝胺。然而，与口腔癌病因相关的无烟烟草制品相关细菌组操纵全身炎症和其他信号通路的潜力将成为口腔癌的危险因素。此外，口腔上皮细胞受损会导致口腔层渗漏，导致脂多糖、鞭毛蛋白和毒素等细菌成分的浸润增加。 消费无烟烟草产品会导致口腔层受损和口腔微生物群失调。因此，