The design and development of more effective biopolymer-based drug delivery and controlled release systems are required to improve pharmaceutical products for psychiatric terapies. In this paper, the synthesis of three types of chitosan-based interbiopolyelectrolyte complexes (IBPECs) with olanzapine (OLZ) were evaluated. The proposal is an innovative ecofriendly formulations with potential application in nano-psychiatry. IBPECs were strategically synthesized following zeta potential measurements using chitosan (Ch) as the base material and tripropylphosphate (TPP) and alginate (ALG) as cross-linking biopolymers. The effect of TPP and ALG as a crosslinking agent on particle size, surface charge density and colloidal stability in complex formation of TPP/Ch, ALG/Ch and ALG/TPP/Ch were evaluated before and after the incorporation of OLZ at pH = 5.0. The ζ = f (pH) and ζ = f ([TPP/Ch], [ALG/Ch] or [ALG/TPP + Ch]) profiles allowed us to elucidate the supramolecular assembly mechanisms of each formulation and determine the best physicochemical conditions that maximize OLZ encapsulation.

需要设计和开发更有效的基于生物聚合物的药物递送和控释系统，以改进用于精神科药物的药物产品。在本文中，评估了三种类型的壳聚糖基生物间聚电解质复合物 (IBPEC) 与奥氮平 (OLZ) 的合成。该提案是一种创新的环保配方，具有在纳米精神病学中的潜在应用。IBPECs 是在 zeta 电位测量后使用壳聚糖 (Ch) 作为基础材料和磷酸三丙酯 (TPP) 和藻酸盐 (ALG) 作为交联生物聚合物进行战略合成的。在 pH = 5.0 下加入 OLZ 之前和之后，评估了 TPP 和 ALG 作为交联剂对 TPP/Ch、ALG/Ch 和 ALG/TPP/Ch 复合物形成过程中粒径、表面电荷密度和胶体稳定性的影响.