Genetic risk for severe COVID-19 correlates with lower inflammatory marker levels in a SARS-CoV-2-negative cohort,Clinical & Translational Immunology

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Genetic risk for severe COVID-19 correlates with lower inflammatory marker levels in a SARS-CoV-2-negative cohort
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-06-06 , DOI: 10.1002/cti2.1292
Timothy R Powell _{1,

2} , Matthew Hotopf _{3,

4} , Stephani L Hatch ₃ , Gerome Breen ₂ , Rodrigo R R Duarte _{1,

2} , Douglas F Nixon ₁

Affiliation

It remains unknown how inflammatory marker levels differ amongst individuals susceptible to coronavirus disease 2019 (COVID-19), prior to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the onset of the cytokine storm. We used genetic risk scores to model how susceptibility to severe COVID-19 correlates with baseline levels of 35 inflammatory markers, by testing their impact in a SARS-CoV-2-negative population cohort. Because of the established effects of age and body mass index on severe COVID-19 risk, we further considered how these variables interacted with genetic risk to affect inflammatory marker levels.

中文翻译：

严重 COVID-19 的遗传风险与 SARS-CoV-2 阴性队列中较低的炎症标志物水平相关

在严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 感染和细胞因子风暴开始之前，易患冠状病毒病 2019 (COVID-19) 的个体之间的炎症标志物水平有何不同仍然未知。我们使用遗传风险评分来模拟对严重 COVID-19 的易感性如何与 35 种炎症标志物的基线水平相关，通过测试它们在 SARS-CoV-2 阴性人群队列中的影响。由于年龄和体重指数对严重 COVID-19 风险的既定影响，我们进一步考虑了这些变量如何与遗传风险相互作用以影响炎症标志物水平。

更新日期：2021-06-07

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