Abstract

1. The study was conducted to evaluate the frequency of polymorphisms in GSTM1 and GSTT1 genes in patients with breast cancer compared with individuals without history of cancer, and the association of these polymorphisms with clinical/epidemiological parameters.

2. There were evaluated 752 women (219 patients and 533 controls). Molecular analysis was performed by the Polymerase Chain Reaction (PCR). Statistical analysis was used multiple logistic regression and descriptive statistics.

3. Age ≥ 50 years (OR = 3.22, 95% CI = 2.30–4.51, p < 0.001) and alcohol consumption (OR = 1.60, 95% CI = 1.13–2.27, p = 0.008) were associated to the development of breast cancer, while smoking and null genotypes GSTM1 and GSTT1 presented no association. GSTM1 and GSTT1 polymorphisms presented no relationship with the clinical and histopathological parameters or molecular subtypes of breast cancer. Ninety-two percent of tumours were invasive ductal, 66% were grade II, 65% were larger than 2 cm, the stages II (35.3%) and III (31.2%) were the most prevalent, and 47.7% were molecular subtype luminal B.

4. Individuals aged ≥ 50 years and alcohol consumers have more chance to developing breast cancer. GSTM1 and GSTT1 polymorphisms are not associated to the risk of breast cancer.

摘要

1. 该研究旨在评估与没有癌症病史的个体相比，乳腺癌患者GSTM1和GSTT1基因多态性的频率，以及这些多态性与临床/流行病学参数的关联。

2. 评估了 752 名女性（219 名患者和 533 名对照）。通过聚合酶链式反应(PCR)进行分子分析。统计分析采用多元逻辑回归和描述性统计。

3. 年龄 ≥ 50 岁（OR = 3.22, 95% CI = 2.30–4.51, p  < 0.001）和饮酒（OR = 1.60, 95% CI = 1.13–2.27, p  = 0.008）与乳腺癌的发生有关，而吸烟和无效基因型GSTM1和GSTT1没有关联。GSTM1和GSTT1多态性与乳腺癌的临床和组织病理学参数或分子亚型无关。92% 的肿瘤为浸润性导管，66% 为 II 级，65% 大于 2 cm，II 期（35.3%）和 III 期（31.2%）最为普遍，47.7% 为分子管腔 B 亚型.

4. 年龄≥50 岁和饮酒的人患乳腺癌的几率更高。GSTM1和GSTT1多态性与患乳腺癌的风险无关。