Undoubtedly, various kinds of nanomaterials are of great significance due to their enormous applications in diverse areas. The structure and productivity of nanomaterials are heavily dependent on the process used for their synthesis. The synthesizing process plays a vital role in shaping nanomaterials effectively for better productivity. The conventional method requires expensive and massive thermal instruments, a huge volume of reagents. This paper aims to develop an Automatic Miniaturized Temperature Controller (AMTC) device for the synthesis of nickel oxide (NiO), copper oxide (CuO) nanoparticles, and nanomicelles. The device features a low-cost, miniaturized, easy-to-operate with plug-and-play power source, precise temperature control, and geotagged real-time data logging facility for the producing nanoparticles. With a temperature accuracy of ± 2 °C, NiO and CuO nanoparticles, and nanomicelles are synthesized on AMTC device, and are subjected to different characterizations to analyze their morphological structure. The obtained mean size of NiO and CuO is 27.14 nm and 85.13 nm respectively. As a proof-of-principle, the synthesized NiO and CuO nanomaterials are validated for electrochemical sensing of dopamine, hydrazine, and uric acid. Furthermore, the study is conducted, wherein, Dexamethasone (Dex) loaded nanomicelles are developed using AMTC device and compared to the conventional thin-film hydration method. Subsequently, as a proof-of-application, the developed nanomicelles are evaluated for transcorneal penetration using exvivo goat cornea model. Ultimately, the proposed device can be utilized for performing a variety of controlled thermal reactions on a minuscule platform with an integrated and miniaturized approach for various applications.

毫无疑问，各种纳米材料因其在不同领域的巨大应用而具有重要意义。纳米材料的结构和生产力在很大程度上取决于其合成过程。合成过程在有效地塑造纳米材料以提高生产力方面起着至关重要的作用。传统方法需要昂贵且庞大的热仪器，大量的试剂。本文旨在开发一种用于合成氧化镍 (NiO)、氧化铜 (CuO) 纳米颗粒和纳米胶束的自动微型温度控制器 (AMTC) 装置。该设备具有低成本、小型化、易于操作的即插即用电源、精确的温度控制和用于生产纳米颗粒的带地理标记的实时数据记录设施。温度精度为 ± 2 °C，NiO 和 CuO 纳米颗粒和纳米胶束在 AMTC 设备上合成，并进行不同的表征以分析其形态结构。获得的 NiO 和 CuO 的平均尺寸分​​别为 27.14 nm 和 85.13 nm。作为原理证明，合成的 NiO 和 CuO 纳米材料经验证可用于多巴胺、肼和尿酸的电化学传感。此外，还进行了研究，其中，使用 AMTC 设备开发了负载地塞米松 (Dex) 的纳米胶束，并与传统的薄膜水化方法进行了比较。随后，作为应用证明，使用离体山羊角膜模型评估开发的纳米胶束的经角膜渗透。最终，