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Mycoviruses and their role in fungal pathogenesis
Current Opinion in Microbiology ( IF 5.9 ) Pub Date : 2021-06-05 , DOI: 10.1016/j.mib.2021.05.007
Ioly Kotta-Loizou 1
Affiliation  

Nowadays, the focus of mycovirology research has expanded from plant pathogenic fungi and mycovirus mediated hypovirulence to include insect and human pathogenic fungi together with a range of mycovirus mediated phenotypes, such as hypervirulence, control of endophytic traits, regulation of metabolite production and drug resistance. In fungus–mycovirus–environmental interactions, the environment and both abiotic and biotic factors play crucial roles in whether and how mycovirus mediated phenotypes are manifest. Mycovirus infections result in alterations in the host transcriptome profile, via protein–protein interactions and triggering of antiviral RNA silencing in the fungus. These alterations, in combination with the environmental factors, may result in desirable phenotypic traits for the host, for us and in some cases for both.



中文翻译:

真菌病毒及其在真菌发病机制中的作用

如今,真菌病毒学研究的重点已从植物病原真菌和真菌病毒介导的低毒力扩展到包括昆虫和人类病原真菌以及一系列真菌病毒介导的表型,如超毒力、内生性状控制、代谢物产生的调节和耐药性。在真菌-真菌病毒-环境相互作用中,环境以及非生物和生物因素在真菌病毒介导的表型是否以及如何表现方面起着至关重要的作用。真菌病毒感染通过蛋白质-蛋白质相互作用和触发真菌中的抗病毒 RNA 沉默导致宿主转录组谱的改变。这些改变与环境因素相结合,可能会导致宿主、我们以及在某些情况下两者的理想表型特征。

更新日期:2021-06-07
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