Docking-based generation of antibodies mimicking Cry1A/1B protein binding sites as potential insecticidal agents against diamondback moth (Plutella xylostella),Pest Management Science

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Docking-based generation of antibodies mimicking Cry1A/1B protein binding sites as potential insecticidal agents against diamondback moth (Plutella xylostella)
Pest Management Science ( IF 3.8 ) Pub Date : 2021-06-06 , DOI: 10.1002/ps.6499
Yajing Xie ₁ , Chongxin Xu ₁ , Meijing Gao ₁ , Xiao Zhang ₁ , Lina Lu ₁ , Xiaodan Hu ₁ , Wei Chen ₁ , Juan L Jurat-Fuentes ₂ , Qing Zhu ₁ , Yuan Liu ₁ , Manman Lin ₁ , Jianfeng Zhong ₁ , Xianjin Liu ₁

Affiliation

Broad use of insecticidal Cry proteins from Bacillus thuringiensis in biopesticides and transgenic crops has resulted in cases of practical field resistance, highlighting the need for novel approaches to insect control. Previously we described an anti-Cry1Ab idiotypic-antibody (B12-scFv) displaying toxicity against rice leafroller (Cnaphalocrocis medinalis) larvae, supporting the potential of antibodies for pest control. The goal of the present study was to generate insecticidal antibodies against diamondback moth (Plutella xylostella) larvae.

中文翻译：

基于对接的抗体生成模拟 Cry1A/1B 蛋白结合位点作为潜在杀虫剂对抗小菜蛾 (Plutella xylostella)

来自苏云金芽孢杆菌的杀虫 Cry 蛋白在生物农药和转基因作物中的广泛应用导致了实际的田间抗性，突出了对昆虫控制新方法的需求。之前我们描述了一种抗 Cry1Ab 独特型抗体 (B12-scFv)，它对水稻卷叶虫( Cnaphalocrocis medinalis ) 幼虫表现出毒性，支持抗体控制害虫的潜力。本研究的目标是产生针对小菜蛾（Plutella xylostella）幼虫的杀虫抗体。

更新日期：2021-06-06

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