One-flow upscaling neutralization of an organophosphonate-derived pesticide/nerve agent simulant to value-added chemicals in a novel Teflon microreactor platform,Reaction Chemistry & Engineering

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One-flow upscaling neutralization of an organophosphonate-derived pesticide/nerve agent simulant to value-added chemicals in a novel Teflon microreactor platform
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2021-6-6 , DOI: 10.1039/d1re00147g
Brijesh M. Sharma _{1,

2,

3,

4,

5} , Se-Jun Yim _{1,

2,

3,

4,

5} , Arun Nikam _{1,

2,

3,

4,

5} , Gwang-Noh Ahn _{1,

2,

3,

4,

5} , Dong-Pyo Kim _{1,

2,

3,

4,

5}

Affiliation

Synthesizing value-added products from chemical warfare agents is a concept well beyond the usual notion of simply neutralizing the agents. We put into practice here such a concept in converting paraoxon, a nerve agent simulant, to paracetamol, an active pharmaceutical ingredient (API). A portable and compact platform consisting of configurable modules based on robust Teflon plate microreactors (TPMs) is devised for neutralization of paraoxon as well as consecutive three-step synthesis of paracetamol in a one-flow manner. The numbered-up TPM platform enables kilogram-scale detoxification of paraoxon within a processing time of 1.5 min at a rate of 28 g h⁻¹ (0.7 kg per day), while another platform in small but configurable system delivers the API in one flow under the pre-optimized conditions on the three-step chemistry established by a capillary reactor. The portability and robust nature of the platform make it suitable for transport and on-site use on a large scale at military installations as well as in chemical industries.

中文翻译：

在新型 Teflon 微反应器平台中对有机膦酸盐衍生的农药/神经毒剂模拟物进行单流放大中和以增加附加值的化学品

从化学战剂合成增值产品是一个远远超出简单中和化学剂的通常概念的概念。我们在这里实施了这样一个概念，即将对氧磷（一种神经毒剂模拟物）转化为对乙酰氨基酚（一种活性药物成分 (API)）。一个便携式紧凑型平台由基于坚固的特氟龙板微反应器 (TPM) 的可配置模块组成，旨在以单流方式中和对氧磷以及对乙酰氨基酚的连续三步合成。编号的 TPM 平台能够在 1.5 分钟的处理时间内以 28 gh ^-1的速率对对氧磷进行公斤级解毒（每天 0.7 公斤），而小型但可配置的系统中的另一个平台在毛细管反应器建立的三步化学的预先优化条件下，以一个流程提供 API。该平台的便携性和坚固性使其适合在军事设施和化学工业中大规模运输和现场使用。

更新日期：2021-06-07

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