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Sublimation thermodynamics of antifungal drugs: Tioconazole, miconazole and climbazole
Fluid Phase Equilibria ( IF 2.8 ) Pub Date : 2021-06-06 , DOI: 10.1016/j.fluid.2021.113098
Svetlana Blokhina , Marina Ol'khovich , Angelica Sharapova , German Perlovich

The temperature dependence of the saturated vapour pressure of the antifungal drugs – tioconazole (TCZ), miconazole (MCZ) and climbazole (CLZ) – was determined by the inert gas carrier transfer method. The standard molar enthalpies of sublimation at T = 298.15 K calculated from these data were 117.2 ± 0.5 kJ·mol-1 for TCZ ± 0.9, 106.2 ± 1.0 kJ·mol-1 for MCZ and 113.3 kJ·mol-1for CLZ. The vaporization and sublimation enthalpies of the compounds were found by the Langmuir and Clausius-Clapeyron equations without determining the vapour pressures of the drugs. Sublimation enthalpies derived by both these methods were in good agreement. It was shown that it was possible to estimate the thermodynamic sublimation functions by applying the space clusterization approach to the studied and structurally related compounds. In addition, the temperature and enthalpy of fusion of the compounds were measured by differential scanning calorimetry.



中文翻译:

抗真菌药物的升华热力学:噻康唑、咪康唑和克洛姆唑

抗真菌药物——噻康唑 (TCZ)、咪康唑 (MCZ) 和克洛姆唑 (CLZ)——的饱和蒸气压的温度依赖性是通过惰性气体载体转移方法确定的。从这些数据计算的 T = 298.15 K 的标准升华摩尔焓为 117.2 ± 0.5 kJ·mol -1 TCZ ± 0.9、106.2 ± 1.0 kJ·mol -1 MCZ 和 113.3 kJ·mol -1对于 CLZ。化合物的汽化和升华焓由朗缪尔方程和克劳修斯-克拉佩龙方程求出,而没有确定药物的蒸气压。这两种方法得出的升华焓非常一致。结果表明,通过将空间聚类方法应用于研究的和结构相关的化合物,可以估计热力学升华函数。此外,通过差示扫描量热法测量化合物的温度和熔化焓。

更新日期:2021-06-17
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