The purpose of this study was to examine the responses of growth hormone (GH) and insulin-like growth factor-I (IGFI) to intense heavy resistance exercise in highly trained men and women to determine what sex-dependent responses may exist. Subjects were highly resistance trained men (N = 8, Mean ± SD; age, yrs., 21 ± 1, height, cm, 175.3 ± 6.7, body mass, kg, 87.0 ± 18.5, % body fat, 15.2 ± 5.4, squat X body mass, 2.1 ± 0.4; and women (N = 7; Mean ± SD, age, yrs. 24 ± 5, height, cm 164.6 ± 6.7, body mass, kg 76.4 ± 8.8, % body fat, 26.9 ± 5.3, squat X body mass, 1.7 ± 0.6). An acute resistance exercise test protocol (ARET) consisted of 6 sets of 10 repetitions at 80% of the 1 RM with 2 min rest between sets was used as the stressor. Blood samples were obtained pre-exercise, after 3 sets, and then immediately after exercise (IP), 5, 15, 30, and 70 min post-exercise for determination of blood lactate (HLa), and plasma glucose, insulin, cortisol, and GH. Determination of plasma concentrations of IGFI, IGF binding proteins 1, 2, and 3 along with molecular weight isoform factions were determined at pre, IP and 70 min. GH significantly (P ≤ 0.05) increased at all time points with resting concentrations significantly higher in women. Significant increases were observed for HLa, glucose, insulin, and cortisol with exercise and into recovery with no sex-dependent observations. Women showed IGF-I values that were higher than men at all times points with both seeing exercise increases. IGFBP-1 and 2 showed increase with exercise with no sex-dependent differences. IGFBP-3 concentrations were higher in women at all-time points with no exercise induced changes. Both women and men saw an exercise induced increase with significantly higher values in GH in only the mid-range (30-60 kD) isoform. Only women saw an exercise induced increase with significantly higher values for IGF fractions only in the mid-range (30–60 kD) isoform, which were significantly greater than the men at the IP and 70 min post-exercise time points. In conclusion, the salient findings of this investigation were that in highly resistance trained men and women, sexual dimorphisms exist but appear different from our prior work in untrained men and women and appear to support a sexual dimorphism related to compensatory aspects in women for anabolic mediating mechanisms in cellular interactions.

本研究的目的是检查生长激素 (GH) 和胰岛素样生长因子-I (IGF I) 对训练有素的男性和女性的高强度抗阻运动的反应，以确定可能存在哪些性别依赖性反应。受试者是受过高度抗阻训练的男性（N  = 8，平均值 ± SD；年龄，岁，21 ± 1，身高，厘米，175.3 ± 6.7，体重，公斤，87.0 ± 18.5，体脂百分比，15.2 ± 5.4，深蹲X 体重，2.1 ± 0.4；和女性（N = 7; 平均值±标准差，年龄，岁。24 ± 5，身高，cm 164.6 ± 6.7，体重，kg 76.4 ± 8.8，体脂百分比，26.9 ± 5.3，深蹲 X 体重，1.7 ± 0.6)。急性阻力运动测试方案 (ARET) 由 6 组 10 次重复组成，每组 1 RM 的 80%，组间休息 2 分钟作为压力源。运动前、3 组后、运动后 (IP)、运动后 5、15、30 和 70 分钟采集血样，用于测定血乳酸 (HLa) 和血浆葡萄糖、胰岛素、皮质醇、和GH。在前、IP 和 70 分钟测定 IGF I、IGF 结合蛋白 1、2 和 3 以及分子量异构体的血浆浓度。GH显着（P ≤ 0.05) 在所有时间点增加，女性的静息浓度显着升高。观察到 HLa、葡萄糖、胰岛素和皮质醇随着运动和恢复而显着增加，没有性别依赖性观察。女性在任何时候都表现出高于男性的 IGF-I 值，并且两者都看到运动增加。IGFBP-1 和 2 显示随着运动而增加，没有性别依赖性差异。在没有运动引起的变化的所有时间点，女性的 IGFBP-3 浓度较高。女性和男性都看到运动引起的增加，仅在中等范围 (30-60 kD) 异构体中 GH 值显着升高。只有女性看到运动引起的增加，仅在中等范围（30-60 kD）同种型中，IGF 分数的值显着升高，在 IP 和运动后 70 分钟时间点显着大于男性。总之，这项调查的显着发现是，在接受过高度抗阻训练的男性和女性中，存在性二态性，但似乎与我们之前在未经训练的男性和女性中的工作不同，并且似乎支持与女性合成代谢介导的补偿方面相关的性二态性细胞相互作用的机制。