Brain Injury ( IF 1.5 ) Pub Date : 2021-06-06 , DOI: 10.1080/02699052.2021.1929487 Melissa Biscardi 1 , Reema Shafi 1 , Nora Cullen 2 , Gillian Einstein 3 , Angela Colantonio 1
ABSTRACT
Objectives: Primary: To explore anti-Müllerian Hormone (AMH) levels in community dwelling women following TBI. Secondary: To explore the relation of AMH to menstrual cycle, cognition, distress and symptoms of menopause.
Setting: Large adult TBI outpatient clinic in Toronto Canada.
Research design: Prospective study of 10 women with persistent symptoms who were one or more years post TBI.
Methods: Consenting participants provided a serum sample for AMH levels, and completed the Menopause Rating Scale (MRS), Symptom Checklist-90 r (SCL-90 r), Repeatable Battery for the Assessment of Neurological Status (RBANS) and a health questionnaire.
Main outcomes and results: This study found lower than expected levels of AMH in 50% of participants relative to age matched norms and 50% of participants experienced new onset of menstrual changes. Also notable were findings of lower-than-expected cognitive scores in women over 35 and reports of menopause-related symptoms across all ages groups.
Conclusions: As our understanding of the role of AMH grows, examining changes in this novel biomarker in the long-term post-TBI is warranted. Future research should be sufficiently powered to expand on and validate the study’s findings.
中文翻译:
TBI 后持续症状女性群体的绝经、抗苗勒管激素和认知:未来研究的一个案例
摘要
目的: 主要: 探讨 TBI 后社区居住妇女的抗苗勒管激素 (AMH) 水平。次要:探讨AMH与月经周期、认知、痛苦和更年期症状的关系。
地点:加拿大多伦多的大型成人 TBI 门诊。
研究设计:对 10 名在 TBI 后一年或以上有持续症状的女性进行的前瞻性研究。
方法:同意的参与者提供了 AMH 水平的血清样本,并完成了更年期评定量表 (MRS)、症状检查表-90 r (SCL-90 r)、用于评估神经状态的可重复电池 (RBANS) 和健康问卷。
主要结果和结果:本研究发现,相对于年龄匹配的标准,50% 的参与者的 AMH 水平低于预期,50% 的参与者经历了新的月经变化。同样值得注意的是 35 岁以上女性的认知评分低于预期,以及所有年龄段的更年期相关症状的报告。
结论:随着我们对 AMH 作用的理解不断加深,有必要在 TBI 后长期检查这种新型生物标志物的变化。未来的研究应该有足够的动力来扩展和验证研究结果。