During the current SARS-CoV2 pandemic, as well as earlier SARS and MERS epidemics, it has been observed that COVID19-positive women on average tend to have milder symptoms and lower fatality rates than men. There is a number of differences between the sexes known to contribute to different immune responses and severity of the disease, one being the effect of estrogen via estrogen receptor signalling. We wondered if estrogen might also affect the SARS-CoV2 more directly, perhaps by binding to the surface glycoprotein (S protein), thus possibly reducing its infectivity.

中文翻译：

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SARS-Cov2 S 蛋白具有潜在的雌激素结合位点。

在当前的 SARS-CoV2 大流行以及早期的 SARS 和 MERS 流行期间，据观察，COVID19 阳性女性的平均症状往往比男性更轻，死亡率更低。已知导致不同免疫反应和疾病严重程度的性别之间存在许多差异，其中之一是雌激素通过雌激素受体信号传导的作用。我们想知道雌激素是否也可能更直接地影响 SARS-CoV2，可能是通过与表面糖蛋白 (S 蛋白) 结合，从而可能降低其传染性。