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Feeding Rats Medium-Chain Triglycerides and Tomato Powder Increases Liver Lycopene Content and Reduces the Expression of Genes Related to Lipid Metabolism in the Liver
ACS Food Science & Technology ( IF 2.6 ) Pub Date : 2021-06-04 , DOI: 10.1021/acsfoodscitech.0c00155 Mayu Kimura 1 , Sayaka Tamura 2 , Shiori Ishiyama 3 , Kazuki Mochizuki 1, 2, 3
ACS Food Science & Technology ( IF 2.6 ) Pub Date : 2021-06-04 , DOI: 10.1021/acsfoodscitech.0c00155 Mayu Kimura 1 , Sayaka Tamura 2 , Shiori Ishiyama 3 , Kazuki Mochizuki 1, 2, 3
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Lycopene quenches reactive oxygen species effectively; however, its bioavailability is low owing to its high lipid solubility. Here, we assessed whether feeding Sprague–Dawley rats medium-chain triglycerides (MCTs), which promote the emulsification of lipid-soluble food components and are metabolized more rapidly than long-chain triglycerides (LCTs), along with tomato powder (T) affects lycopene accumulation and metabolism in the liver. Liver lycopene contents were higher in MCT+T-fed rats than in LCT+T-fed rats. Serum levels of high molecular weight adiponectin were markedly higher in MCT+T-fed rats than in the other groups. MCT+T-fed rats exhibited lower liver triglycerides compared with LCT+T-fed rats. Furthermore, the elevated Acaca and Scd1 mRNA expression levels observed in rats fed MCTs were decreased in rats fed MCT+T. These results suggest that feeding rats MCTs and T increased the liver lycopene content and systemic insulin sensitivity, improving lipid metabolism in the liver.
中文翻译：
喂养大鼠中链甘油三酯和番茄粉可增加肝脏番茄红素含量并降低肝脏脂质代谢相关基因的表达
番茄红素有效地淬灭活性氧；然而，由于其高脂溶性，其生物利用度较低。在这里，我们评估了喂养 Sprague-Dawley 大鼠中链甘油三酯 (MCT) 是否会影响脂溶性食物成分的乳化，并且比长链甘油三酯 (LCT) 代谢更快，以及番茄粉 (T) 是否会影响番茄红素在肝脏中的积累和代谢。MCT+T喂养的大鼠肝脏番茄红素含量高于LCT+T喂养的大鼠。MCT+T 喂养大鼠的血清高分子量脂联素水平明显高于其他组。与 LCT+T 喂养的大鼠相比，MCT+T 喂养的大鼠表现出较低的肝脏甘油三酯。此外，升高的ACACA和SCD1在喂食 MCT+T 的大鼠中观察到的 mRNA 表达水平降低。这些结果表明，喂养大鼠 MCTs 和 T 增加了肝脏番茄红素含量和全身胰岛素敏感性，改善了肝脏中的脂质代谢。
更新日期：2021-07-16
中文翻译：
喂养大鼠中链甘油三酯和番茄粉可增加肝脏番茄红素含量并降低肝脏脂质代谢相关基因的表达
番茄红素有效地淬灭活性氧；然而，由于其高脂溶性，其生物利用度较低。在这里，我们评估了喂养 Sprague-Dawley 大鼠中链甘油三酯 (MCT) 是否会影响脂溶性食物成分的乳化，并且比长链甘油三酯 (LCT) 代谢更快，以及番茄粉 (T) 是否会影响番茄红素在肝脏中的积累和代谢。MCT+T喂养的大鼠肝脏番茄红素含量高于LCT+T喂养的大鼠。MCT+T 喂养大鼠的血清高分子量脂联素水平明显高于其他组。与 LCT+T 喂养的大鼠相比，MCT+T 喂养的大鼠表现出较低的肝脏甘油三酯。此外，升高的ACACA和SCD1在喂食 MCT+T 的大鼠中观察到的 mRNA 表达水平降低。这些结果表明，喂养大鼠 MCTs 和 T 增加了肝脏番茄红素含量和全身胰岛素敏感性，改善了肝脏中的脂质代谢。
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