With this letter to Editor, we aim at offering our viewpoint on the potential use of the spa resources to contribute to the treatment of persistent COVID-19 sequelae. In particular, our argumentations focus on the comprehensive management of fatigue persisting after the resolution of the acute infection. This sequela seems to be the most frequent disabling outcome, leading to a delay in social reintegration and return to working life.

We suggest that spa facilities including multidisciplinary interventions and trained staffs could be an appropriate setting for providing rehabilitative protocols to treat chronic fatigue in post COVID-19 subjects. Spa treatments may improve the physical symptoms of chronic fatigue and modulate the immune imbalance, reducing persisting inflammation. Moreover, in the spa setting, specific respiratory rehabilitation and neuropsychological interventions could be provided. The rehabilitative protocol could also properly address comorbidities.

In conclusion, respecting the hygiene and preventive measures, the spa setting could represent the appropriate environment to take care of post-COVID chronic fatigue, offering adequate and multidisciplinary rehabilitation protocols. Further, prospective trials on this topic are needed to fully evaluate the positive impact of a comprehensive rehabilitative treatment in the spa environment for subjects with post-COVID-19 fatigue.

通过这封给编辑的信，我们旨在就水疗资源的潜在用途提供我们的观点，以促进治疗持续性 COVID-19 后遗症。特别是，我们的论点集中在急性感染消退后持续疲劳的综合管理上。这种后遗症似乎是最常见的致残结果，导致延迟重新融入社会和重返工作生活。

我们建议，包括多学科干预和训练有素的员工在内的水疗设施可能是提供康复方案以治疗 COVID-19 后受试者慢性疲劳的合适环境。水疗可以改善慢性疲劳的身体症状，调节免疫失衡，减少持续的炎症。此外，在水疗环境中，可以提供特定的呼吸康复和神经心理干预。康复方案还可以正确解决合并症。

总之，在尊重卫生和预防措施的前提下，水疗设施可以代表照顾 COVID 后慢性疲劳的适当环境，提供充分和多学科的康复方案。此外，需要就该主题进行前瞻性试验，以全面评估在水疗环境中对 COVID-19 后疲劳受试者进行综合康复治疗的积极影响。