Objective

Quantitative Magnetic Resonance Imaging sequences have been investigated as objective imaging biomarkers of fibrosis and inflammation in Crohn’s disease.

Aim

To determine the repeatability and inter- and intra-observer agreement of these measures in the prepared small bowel wall.

Methods

Ten healthy participants were scanned at 3 T on 2 separate occasions using T1 and T2 relaxometry, IVIM-DWI and MT sequences. Test–retest repeatability was assessed using the coefficient of variation (CoV) and intra-class correlation coefficients (ICCs) were used to evaluate the intra- and inter-observer agreement

Results

Test–retest repeatability in the bowel wall was excellent for apparent diffusion coefficient (ADC), magnetisation transfer ratio (MTR), T1, and diffusion coefficient D (CoV 5%, 7%, 8%, and 10%, respectively), good for perfusion fraction (PF) (CoV 20%) and acceptable for T2 (CoV 21%). Inter-observer agreement was good for the T2, D and ADC (ICC = 0.89, 0.86, 0.76, respectively) and moderate for T1 (ICC = 0.55). Intra-observer agreement was similar to inter-observer agreement.

Discussion

This study showed variable results between the different parameters measured. Test–retest repeatability was at least acceptable for all parameters except pseudo-diffusion coefficient D*. Good inter- and intra-observer agreement was obtained for T2, ADC and D, with these parameters performing best in this technical validation study.

中文翻译：

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对非对比 MRI 序列进行重测评估，以表征和量化健康参与者的小肠壁

客观的

定量磁共振成像序列已被研究为克罗恩病中纤维化和炎症的客观成像生物标志物。

目的

确定这些措施在准备好的小肠壁中的可重复性和观察者间和观察者内的一致性。

方法

使用 T1 和 T2 弛豫测量法、IVIM-DWI 和 MT 序列在 2 个不同的场合以 3 T 扫描 10 名健康参与者。使用变异系数 (CoV) 评估重测重复性，并使用类内相关系数 (ICC) 评估观察者内和观察者间的一致性

结果

对于表观扩散系数 (ADC)、磁化传递比 (MTR)、T1 和扩散系数 D（CoV 分别为 5%、7%、8% 和 10%），肠壁的重测重复性非常好，良好灌注分数 (PF) (CoV 20%) 和 T2 (CoV 21%) 可接受。观察者间一致性对于 T2、D 和 ADC（ICC = 0.89、0.86、0.76，分别）和 T1（ICC = 0.55）适中。观察者内协议类似于观察者间协议。

讨论

这项研究显示了测量的不同参数之间的可变结果。除伪扩散系数 D* 外，所有参数的重测重复性至少是可以接受的。T2、ADC 和 D 获得了良好的观察者间和观察者内一致性，这些参数在这项技术验证研究中表现最佳。