Vanillin, the main constituents of vanillin beans, has been reported to exhibit anti-inflammatory effects. However, the effects of vanillin on the cadmium-induced lung injury are still unclear. Therefore, we assay whether vanillin has potential preventive activity on cadmium-induced lung injury in mice. Mice were given vanillin (5, 10, 20 mg/kg) and treated with cadmium for 7 days. The detection data of vanillin on lung tissue changes were analyzed after the cadmium treatment. The results displayed that vanillin obviously decreased the lung histological alterations and myeloperoxidase (MPO) activity. Vanillin also suppressed the levels of TNF-α, IL-1β, and IL-6 in BALF. Furthermore, vanillin prevented cadmium-induced NF-κB activation and upregulation the expression of tight junction protein ZO-1 and occludin. In addition, vanillin significantly increased the expression of aryl hydrocarbon receptor (AhR), and inhibition of AhR by its agonist could reverse the protective effects of vanillin on cadmium-induced lung injury. To sum up, vanillin could be a potential drug for the treatment of cadmium-induced lung injury.

香草醛是香草醛豆的主要成分，据报道具有抗炎作用。然而，香草醛对镉引起的肺损伤的影响仍不清楚。因此，我们检测香草醛是否对镉引起的小鼠肺损伤具有潜在的预防活性。给小鼠服用香草醛（5、10、20 mg/kg）并用镉治疗 7 天。分析镉处理后香草醛对肺组织变化的检测数据。结果显示，香草醛明显降低肺组织学改变和髓过氧化物酶（MPO）活性。香兰素还抑制 BALF 中 TNF-α、IL-1β 和 IL-6 的水平。此外，香草醛可防止镉诱导的 NF-κB 激活并上调紧密连接蛋白 ZO-1 和 occludin 的表达。此外，香草醛显着增加芳烃受体（AhR）的表达，其激动剂抑制AhR可以逆转香草醛对镉诱导的肺损伤的保护作用。综上所述，香草醛可能是治疗镉引起的肺损伤的潜在药物。