In the neuroHIV literature, cognitive reserve has most often been operationalized using education, occupation, and IQ. The effects of other cognitively stimulating activities that might be more amenable to interventions have been little studied. The purpose of this study was to develop an index of cognitive reserve in people with HIV, combining multiple indicators of cognitively stimulating lifetime experiences into a single value.

The data set was obtained from a Canadian longitudinal study (N = 856). Potential indicators of cognitive reserve captured at the study entry included education, occupation, engagement in six cognitively stimulating activities, number of languages spoken, and social resources. Cognitive performance was measured using a computerized test battery. A cognitive reserve index was formulated using logistic regression weights. For the evidence on concurrent and predictive validity of the index, the measures of cognition and self-reported everyday functioning were each regressed on the index scores at study entry and at the last follow-up [mean duration: 25.9 months (SD 7.2)], respectively. Corresponding regression coefficients and 95% confidence intervals (CIs) were computed.

Professional sports [odds ratio (OR): 2.9; 95% CI 0.59–14.7], visual and performance arts (any level of engagement), professional/amateur music, complex video gaming and competitive games, and travel outside North America were associated with higher cognitive functioning. The effects of cognitive reserve on the outcomes at the last follow-up visit were closely similar to those at study entry.

This work contributes evidence toward the relative benefit of engaging in specific cognitively stimulating life experiences in HIV.

在神经 HIV 文献中，认知储备最常通过教育、职业和智商来操作。其他可能更适合干预的认知刺激活动的影响很少被研究。本研究的目的是开发一个艾滋病病毒感染者的认知储备指数，将认知刺激一生经历的多个指标组合成一个单一的值。

数据集来自加拿大纵向研究 (N = 856)。在研究条目中捕获的认知储备的潜在指标包括教育、职业、参与六种认知刺激活动、使用的语言数量和社会资源。使用计算机化测试电池测量认知能力。使用逻辑回归权重制定认知储备指数。对于该指数的同时和预测有效性的证据，认知和自我报告的日常功能的测量值分别在研究开始和最后一次随访时的指数得分上进行回归 [平均持续时间：25.9 个月 (SD 7.2)] ， 分别。计算了相应的回归系数和 95% 置信区间 (CI)。

职业运动[赔率比（OR）：2.9；95% CI 0.59–14.7]、视觉和表演艺术（任何参与程度）、专业/业余音乐、复杂的视频游戏和竞技游戏以及北美以外的旅行与更高的认知功能相关。认知储备对最后一次随访结果的影响与进入研究时的结果非常相似。

这项工作为参与特定的认知刺激性 HIV 生活经历的相对益处提供了证据。