Abstract

Four bare silica particle carriers with different particle sizes and functional organic-inorganic silica particles (SiO₂-2/P4VP-psl) “grafted” by P4VP-psl (polypyridinium salt) were selected to test their antibacterial and antifouling activities. The relationships between particle sizes, grafting degrees of pyridinium salt unit and their antibacterial ability were investigated by using Escherichia coli (E. coli) ATTC25922 as model bacterium and calculated by the colony count method. The results showed that silica particle sizes did not work in its antibacterial and antifouling activities. Functional SiO₂-2/P4VP-psl possessed both the good antibacterial, antifouling activities of zwitterionic polymers, and the stability advantage of inorganic particle, which was environmental friendly disinfection materials in purifying water. The antibacterial rate was almost 100%. The stability of SiO₂-2/P4VP-psl in bovine serum albumin solutions was very excellent with the unchanged particle size for 60 h. Moreover, the higher the grafting degree of pyridinium salt unit was, the stronger the sterilizing ability of SiO₂-2/P4VP-psl was.

摘要

选择四种不同粒径的裸二氧化硅颗粒载体和由P4VP-psl（聚吡啶盐）“接枝”的功能性有机-无机二氧化硅颗粒（SiO ₂ -2 / P4VP-psl）来测试其抗菌和防污活性。以大肠杆菌( E.coli )ATTC25922为模型菌,采用菌落计数法,研究了粒径、吡啶盐单元接枝度与其抗菌能力之间的关系。结果表明，二氧化硅粒径在其抗菌和防污活性中不起作用。功能性SiO ₂-2/P4VP-psl兼具两性离子聚合物良好的抗菌、防污活性和无机颗粒的稳定性优势，是一种环保型净化水消毒材料。抗菌率几乎达到100%。SiO ₂ -2/P4VP-psl 在牛血清白蛋白溶液中的稳定性非常好，粒径保持 60 小时不变。此外，吡啶鎓盐单元的接枝度越高，SiO ₂ -2 /P4VP-psl的杀菌能力越强。