Inhibiting USP14 ameliorates inflammatory responses in trophoblast cells by suppressing MAPK/NF-κB signaling,Immunity, Inflammation and Disease

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Inhibiting USP14 ameliorates inflammatory responses in trophoblast cells by suppressing MAPK/NF-κB signaling
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2021-06-05 , DOI: 10.1002/iid3.465
Yingzi Zhao ₁ , Fang Zong ₁

Affiliation

Preeclampsia can cause severe consequences for pregnant women and infants, and developing effective medicine or methods to prevent or treat patients with preeclampsia is urgently needed. Ubiquitin-specific protease 14 (USP14) has emerged as a critical regulator in the development of human cancers and neurodegenerative diseases. However, its role in preeclampsia remains elusive.

中文翻译：

抑制 USP14 通过抑制 MAPK/NF-κB 信号传导改善滋养层细胞的炎症反应

先兆子痫会对孕妇和婴儿造成严重后果，迫切需要开发有效的药物或方法来预防或治疗先兆子痫患者。泛素特异性蛋白酶 14 (USP14) 已成为人类癌症和神经退行性疾病发展的关键调节因子。然而，它在先兆子痫中的作用仍然难以捉摸。

更新日期：2021-08-07

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