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Mitotic poleward flux: Finding balance between microtubule dynamics and sliding
BioEssays ( IF 3.2 ) Pub Date : 2021-06-04 , DOI: 10.1002/bies.202100079
Marin Barisic 1, 2 , Girish Rajendraprasad 1
Affiliation  

Continuous poleward motion of microtubules in metazoan mitotic spindles has been fascinating generations of cell biologists over the last several decades. In human cells, this so-called poleward flux was recently shown to be driven by the coordinated action of four mitotic kinesins. The sliding activities of kinesin-5/EG5 and kinesin-12/KIF15 are sequentially supported by kinesin-7/CENP-E at kinetochores and kinesin-4/KIF4A on chromosome arms, with the individual contributions peaking during prometaphase and metaphase, respectively. Although recent data elucidate the molecular mechanism underlying this cellular phenomenon, the functional roles of microtubule poleward flux during cell division remain largely elusive. Here, we discuss potential contribution of microtubule flux engine to various essential processes at different stages of mitosis.

中文翻译:

有丝分裂极向通量:在微管动力学和滑动之间寻找平衡

在过去的几十年里,后生动物有丝分裂纺锤体中微管的连续向极运动一直是细胞生物学家的迷人之处。在人类细胞中,这种所谓的向极通量最近被证明是由四种有丝分裂驱动蛋白的协调作用驱动的。kinesin-5/EG5 和 kinesin-12/KIF15 的滑动活动依次由动粒上的 kinesin-7/CENP-E 和染色体臂上的 kinesin-4/KIF4A 支持,个体贡献分别在前中期和中期达到峰值。尽管最近的数据阐明了这种细胞现象背后的分子机制,但微管向极通量在细胞分裂过程中的功能作用在很大程度上仍然难以捉摸。在这里,我们讨论了微管通量引擎对有丝分裂不同阶段的各种基本过程的潜在贡献。
更新日期:2021-07-23
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