Two metal–organic coordination complexes whose chemical formulae were [Co₂(Htpt)₂(H₂O)₂]·CH₃CN}_n (1) and [Co(H₂tpt)₂]·3H₂O (2) based on the polydentate 4-(2,4,6-tricarboxyphenyl)-2,2′,6,2″-terpyridine ligand (H₃tpt) have been synthesized using a hydrothermal reaction method, and their structures were determined via a series of characterization methods. The as-prepared coordination complexes were studied via single-crystal X-ray diffraction, powder X-ray diffraction, elemental analysis, and thermogravimetric analysis. Structural analysis revealed that complex 1 has a 2D-layered structure with a (3,3)-linked hcb network, while complex 2 features discrete structure, which is further extended into a 3D supramolecular network via H-bond interactions. Their treatment activity on osteoarthritis induced by anterior ligament reconstruction was evaluated. First, the inflammatory response in the bone joint was assessed using an enzyme-linked immunosorbent assay detection kit. The activation of the nf-κb signaling routine at the bone joint was assessed using real-time reverse transcription polymerase chain reaction.

化学式为[Co ₂ (Htpt) ₂ (H ₂ O) ₂ ]·CH ₃ CN} _n ( 1 ) 和[Co(H ₂ tpt) ₂ ]·3H ₂ O ( 2 ) 的两种金属有机配位配合物基于多齿 4-(2,4,6-三羧基苯基)-2,2',6,2"-三联吡啶配体 (H ₃tpt) 已使用水热反应方法合成，并通过一系列表征方法确定了它们的结构。通过单晶 X 射线衍射、粉末 X 射线衍射、元素分析和热重分析研究了所制备的配位配合物。结构分析表明，复合物1具有带有 (3,3) 连接的hcb网络的二维分层结构，而复合物2具有离散结构，通过氢键相互作用进一步扩展为 3D 超分子网络。评估了它们对由前韧带重建引起的骨关节炎的治疗活性。首先，使用酶联免疫吸附测定检测试剂盒评估骨关节中的炎症反应。使用实时逆转录聚合酶链反应评估骨关节处 nf-κb 信号通路的激活。