Depression is the leading cause of disability globally and has serious consequences for the individual, their family and for society. Effective, accessible and affordable treatments are urgently needed. In-person group-based mindfulness-based interventions are an effective treatment for depression, but are not widely available and can be costly. Clinician supported use of mindfulness self-help resources such as mindfulness smartphone applications could widen access at a reduced cost, but there are key feasibility questions that need answering. This is a mixed-methods feasibility study of a blended intervention involving the mindfulness smartphone app Headspace alongside six clinician support sessions with mental health treatment seeking adults experiencing moderate to moderately severe symptoms of depression. In line with recommendations for feasibility studies, we examine whether: (1) it is possible to recruit participants to this novel intervention, (2) participants engage with the intervention, (3) participants and clinicians find the intervention acceptable, and (4) pre-post outcomes on measures of depression (primary outcome), anxiety, wellbeing, mindfulness, self-compassion, rumination and worry indicate effectiveness. Findings show that recruitment is feasible with 54 participants enrolled in the intervention within a 6-month window. In terms of engagement, 44.4% completed at least 80% of recommended Headspace sessions and 72.2% of participants attended at least three clinician support sessions. Clinician-supported Headspace was deemed acceptable by participants and clinicians. Pre-post effect sizes were statistically significant and in the small-medium or medium-large range on all outcomes, with an effect size of d = 0.69 (95% CI: 0.34–1.04) for the primary outcome of depression symptom severity. The number of Headspace sessions engaged with was associated with greater reduction in depression symptom severity. Findings suggest that a blended intervention combining Headspace with clinician support has potential as a first-line treatment for moderate/moderately severe depression, but findings are too preliminary to recommend the intervention outside of a research trial. Important caveats are noted including the need for future research to examine predictors of engagement with Headspace sessions so that engagement can be enhanced, to measure the longer term effects of such interventions and to better understand the potential for lasting negative effects of the intervention so that these can be minimised.

抑郁症是全球范围内导致残疾的主要原因，对个人、家庭和社会造成严重后果。迫切需要有效、可及且负担得起的治疗方法。面对面的团体正念干预是一种有效的抑郁症治疗方法，但并不广泛可用，而且成本高昂。临床医生支持使用正念自助资源，如正念智能手机应用程序，可以以更低的成本扩大访问范围，但有一些关键的可行性问题需要回答。这是一项混合干预的混合方法可行性研究，涉及正念智能手机应用程序 Headspace 以及六个临床医生支持会议，以及寻求患有中度至中度抑郁症症状的成年人的心理健康治疗。根据可行性研究的建议，我们检查是否：(1) 是否有可能招募参与者参与这种新型干预，(2) 参与者参与干预，(3) 参与者和临床医生认为干预是可接受的，以及 (4)对抑郁（主要结果）、焦虑、幸福感、正念、自我同情、沉思和担忧的测量的前后结果表明有效性。结果表明，在 6 个月的时间窗口内招募 54 名参与者参加干预是可行的。在参与度方面，44.4% 的人完成了至少 80% 的推荐顶空会议，72.2% 的参与者至少参加了三个临床医生支持会议。参与者和临床医生认为临床医生支持的顶空是可以接受的。 对于抑郁症状严重程度的主要结果，d = 0.69（95% CI：0.34–1.04）。参与顶空会议的次数与抑郁症状严重程度的降低有关。研究结果表明，将 Headspace 与临床医生支持相结合的混合干预措施有可能作为中度/中度重度抑郁症的一线治疗方法，但研究结果过于初步，无法推荐研究试验之外的干预措施。需要注意的重要事项包括未来的研究需要检查参与顶空会议的预测因素，以便提高参与度，衡量此类干预的长期影响，并更好地了解干预的持久负面影响的潜力，以便这些可以最小化。