A study on the physical properties of low melting mixtures and their use as catalysts/solvent in the synthesis of barbiturates,Journal of Heterocyclic Chemistry

当前位置： X-MOL 学术 › J. Heterocycl. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A study on the physical properties of low melting mixtures and their use as catalysts/solvent in the synthesis of barbiturates
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2021-06-04 , DOI: 10.1002/jhet.4315
Letcy V. Theresa ₁ , G. Avudaiappan ₁ , M. Shaibuna ₁ , K. Hiba ₁ , K. Sreekumar ₁

Affiliation

In recent years, deep eutectic solvents have become attractive due to their interesting characteristics such as, physicochemical properties, low cost of components, easiness to prepare, low toxicity, bio-renewability, and biodegradability. In order to make the deep eutectic mixture more cost-effective and renewable, carbohydrate derivatives were linked with deep eutectic mixtures, since, carbohydrates are the most important and widespread renewable compounds on the earth. In this work, we have used low melting mixtures comprised of carbohydrates to create the reaction media for organic transformations. The physical properties such as density, viscosity, acidity, refractive index, surface tension, solubility, glass transition temperature, thermal stability, solvent polarity, and toxicity of the mixture were studied. Low melting mixtures were used as reaction media and catalysts for the effective synthesis of Barbiturates. The reaction between aldehydes and barbituric acid/thiobarbituric acid, and the reaction between aldehydes, barbituric acid/thiobarbituric acid, and malononitrile/dimedone were performed effectively with good to excellent yields. The recyclability of the catalyst/solvent was also established.

中文翻译：

低熔点混合物的物理性质及其在巴比妥酸盐合成中作为催化剂/溶剂的研究

近年来，深共熔溶剂由于其物理化学性质、组分成本低、易于制备、低毒性、生物可再生和生物降解性等有趣特性而变得有吸引力。为了使深共晶混合物更具成本效益和可再生性，碳水化合物衍生物与深共晶混合物相关联，因为碳水化合物是地球上最重要和分布最广的可再生化合物。在这项工作中，我们使用由碳水化合物组成的低熔点混合物来创建有机转化的反应介质。对混合物的密度、粘度、酸度、折射率、表面张力、溶解度、玻璃化转变温度、热稳定性、溶剂极性和毒性等物理性质进行了研究。低熔点混合物被用作反应介质和催化剂以有效合成巴比妥酸盐。醛类与巴比妥酸/硫代巴比妥酸之间的反应，以及醛类、巴比妥酸/硫代巴比妥酸和丙二腈/二甲酮之间的反应均以良好到极好的收率进行。还确定了催化剂/溶剂的可回收性。

更新日期：2021-06-04

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11