Although antiviral antibodies generally confer protective functions, antibodies against dengue virus (DENV) are associated with enhanced disease susceptibility. Antibodies can mediate DENV infection of leukocytes via Fcγ receptors, likely contributing to dengue disease pathogenesis. To determine if this mechanism accounts for variable disease severity, we examined Fab and Fc structures of anti-DENV antibodies from patients before and after infection and with variable disease outcomes. Neither antibody titers nor neutralizing activity correlated with disease severity in DENV-infected populations. Rather, DENV infection induced a specific increase in immunoglobulin G1 (IgG1) afucosylation, and the levels of afucosylated IgG1 were predictive of dengue disease severity. Thus, the IgG1 fucosylation status represents a robust prognostic tool for dengue disease, highlighting the key role of the Fc glycan structure in dengue pathogenesis.

虽然抗病毒抗体通常具有保护功能，但针对登革热病毒 (DENV) 的抗体与增强的疾病易感性有关。抗体可通过 Fcγ 受体介导白细胞的 DENV 感染，可能导致登革热发病机制。为了确定这种机制是否解释了不同的疾病严重程度，我们检查了感染前后患者的抗 DENV 抗体的 Fab 和 Fc 结构以及不同的疾病结果。抗体滴度和中和活性均与 DENV 感染人群的疾病严重程度无关。相反，DENV 感染诱导了免疫球蛋白 G1 (IgG1) 无岩藻糖基化的特异性增加，而无岩藻糖基化 IgG1 的水平可预测登革热疾病的严重程度。因此，