α-Substituted β-mercapto ketone based synthesis of 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles,Chemistry of Heterocyclic Compounds

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α-Substituted β-mercapto ketone based synthesis of 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles
Chemistry of Heterocyclic Compounds ( IF 1.4 ) Pub Date : 2021-06-04 , DOI: 10.1007/s10593-021-02940-4
Larisa А. Baeva , Radik M. Nugumanov , Rail R. Gataullin , Akhnef А. Fatykhov

A novel approach to the synthesis of 3-(alkylsulfanylmethyl)-substituted 1H-indoles was developed based on the Fischer indole synthesis involving accessible β-mercapto ketones. Heterocyclization of 3-[(alkylsulfanyl)methyl]alkan-2-ones and phenylhydrazine by the action of ZnCl₂ in MeOH or EtOH gave previously unknown 3-alkyl-3-[(alkylsulfanyl)methyl]-2-methyl-3H-indoles.

中文翻译：

基于α-取代的β-巯基酮合成3-烷基-3-[(烷基硫烷基)甲基]-2-甲基-3H-吲哚

基于 Fischer 吲哚合成，涉及可接近的 β-巯基酮，开发了一种合成 3-（烷基硫基甲基）-取代的 1 H-吲哚的新方法。通过 ZnCl ₂在 MeOH 或 EtOH 中的作用，3-[(烷基硫烷基)甲基]链烷-2-酮和苯肼的杂环化得到以前未知的 3-烷基-3-[(烷基硫烷基)甲基]-2-甲基-3 H -吲哚。

更新日期：2021-06-04

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