2-Mercapto-1,3,4-triazoles and 2-amino-1,3,4-thiadiazoles were synthesized by successive transformations of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids and their derivatives. The amino group of 5-(4,5-dichloroisothiazol-3-yl)-1,3,4-thiadiazol-2-amine was acylated with 5-phenylisoxazole-3-carboxylic acid chloride. Simple approaches to the preparation of previously unknown heterocyclic assemblies containing two or three azole rings with a high potential for biological activity are described.

中文翻译：

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基于 5-芳基异恶唑-3 衍生物的 5-唑基-2,4-二氢-3H-1,2,4-三唑-3-硫酮和 5-唑基-1,3,4-噻二唑-2-胺的合成-羧酸和 4,5-二氯异噻唑-3-羧酸

2-Mercapto-1,3,4-triazoles 和 2-amino-1,3,4-thiadiazoles 是通过 5-arylisoxazole-和 4,5-dichloroisothiazole-3-羧酸及其衍生物的连续转化合成的。5-(4,5-二氯异噻唑-3-基)-1,3,4-噻二唑-2-胺的氨基用5-苯基异恶唑-3-甲酰氯酰化。描述了制备包含两个或三个具有高生物活性潜力的唑环的以前未知的杂环组件的简单方法。