We conducted a meta-analysis of published data to update and estimate the prevalence of HPV in ovarian cancer. A comprehensive literature search was performed according to the PRISMA guidelines. Eligible articles published from 1989 until 2020 by searching Web of Sciences, Pubmed, Embase, and the Cochrane Library Central databases were gathered. A pooled estimation of HPV prevalence with a 95% confidence interval (CI) was calculated based on a random effect model. Quantitative assessment of heterogeneity was explored using Cochrane test and I². Additionally, publication bias, sensitivity, meta-regression, and subgroup analyses were also performed. Twenty-nine studies involving 2280 patients with ovarian cancer were included. The statistical heterogeneity was high (I² = 88%, P<0.0001). The pooled prevalence of HPV in ovarian cancer cases was 15.9% (95% CI, 11–22). In subgroup analyses, the highest prevalence of HPV was reported by studies from Asia (30.9%; 95% CI, 20–44) and Eastern Europe (29.3%; 95% CI, 4.4–78). Furthermore, the most frequently detected HPV genotype was HPV16 (54%; 95% CI, 27.9–55), followed by HPV18 (23.2%; 95% CI, 18.8–28.2). Our meta-analysis suggests a great difference in the prevalence of HPV detected in ovarian cancer by different studies, which is not seen in strongly HPV-associated cancers such as cervical cancer. However, the prevalence varied markedly by geographic region. Considering the substantial heterogeneity found, more studies with control groups and precise assays measuring HPV mRNA expression are needed to further evaluate the link and causative aetiology between HPV and ovarian cancer.

我们对已发表的数据进行了荟萃分析，以更新和估计卵巢癌中 HPV 的患病率。根据 PRISMA 指南进行了全面的文献检索。收集了从 1989 年到 2020 年通过搜索 Web of Sciences、Pubmed、Embase 和 Cochrane Library Central 数据库发表的符合条件的文章。基于随机效应模型计算具有 95% 置信区间 (CI) 的 HPV 流行率的汇总估计。使用 Cochrane 检验和I ²探索了对异质性的定量评估。此外，还进行了发表偏倚、敏感性、荟萃回归和亚组分析。包括 29 项研究，涉及 2280 名卵巢癌患者。统计异质性高（I ²= 88%，P<0.0001)。卵巢癌病例中 HPV 的汇总患病率为 15.9%（95% CI，11-22）。在亚组分析中，亚洲 (30.9%; 95% CI, 20-44) 和东欧 (29.3%; 95% CI, 4.4-78) 的研究报告了 HPV 的最高流行率。此外，最常检测到的 HPV 基因型是 HPV16（54%；95% CI，27.9-55），其次是 HPV18（23.2%；95% CI，18.8-28.2）。我们的荟萃分析表明，不同研究在卵巢癌中检测到的 HPV 患病率存在​​很大差异，这在宫颈癌等与 HPV 密切相关的癌症中没有发现。然而，流行率因地理区域而异。考虑到发现的实质性异质性，