ABSTRACT

Photothermal therapy (PTT) has attracted broad attention as a promising method for cancer therapy with less severe side effects than conventional radiation therapy, chemotherapy and surgical resection. PTT relies on the photoconversion capacity of photothermal agents (PTAs), and a wide variety of nanomaterials have been employed as PTAs for cancer therapy due to their excellent photothermal properties. The PTAs are systematically or locally administered and become enriched in cancer cells to increase ablation efficiency. In recent years, PTAs and three-dimensional scaffolds have been hybridized to realize the local delivery of PTAs for the repeated ablation of cancer cells. Meanwhile, the composite scaffolds can stimulate the reconstruction and regeneration of the functional tissues and organs after ablation of cancer cells. A variety of composite scaffolds of photothermal nanomaterials have been prepared to combine the advantages of different modalities to maximize their therapeutic efficacy with minimal side effects. The synergistic effects make the composite scaffolds attractive for biomedical applications. This review summarizes these latest advances and discusses the future prospects.

 抽象的

光热疗法（PTT）作为一种有前景的癌症治疗方法而受到广泛关注，其副作用比传统放射疗法、化学疗法和手术切除更轻。 PTT依赖于光热剂（PTA）的光转换能力，多种纳米材料由于其优异的光热特性已被用作癌症治疗的PTA。 PTA 被系统或局部施用并在癌细胞中富集以提高消融效率。近年来，PTAs与三维支架相结合，实现了PTAs的局部递送，从而反复消融癌细胞。同时，复合支架可以刺激癌细胞消融后功能组织和器官的重建和再生。人们已经制备了多种光热纳米材料复合支架，结合不同方式的优点，以最大限度地提高其治疗效果，同时将副作用降至最低。协同效应使复合支架对生物医学应用具有吸引力。本综述总结了这些最新进展并讨论了未来的前景。