Abstract

The protein/cell interactions with the surface at the blood-biomaterial interface generally control the efficiency of biomedical devices. A wide range of active processes and slow kinetics occur simultaneously with many biomaterials in healthcare applications, leading to multiple biological reactions and reduced clinical functions. In this work, we present a brief review of studies as the interface between proteins and biomaterials. These include mechanisms of resistance to proteins, protein-rejecting polyelectrolyte multilayers, and coatings of hydrophilic, polysaccharide and phospholipid nature. The mechanisms required to attain surfaces that resist adhesion include steric exclusion, water-related effects, and volume effects. Also, approaches in the use of hydrophilic, highly hydrated, and electrically neutral coatings have demonstrated a good ability to decrease cell adhesion. Moreover, amongst the available methods, the approach of layer-by-layer deposition has been known as an interesting process to manipulate protein and cell adhesion behavior.

摘要

蛋白质/细胞与血液-生物材料界面表面的相互作用通常控制着生物医学设备的效率。广泛的活性过程和缓慢的动力学与医疗保健应用中的许多生物材料同时发生，导致多种生物反应和临床功能降低。在这项工作中，我们简要回顾了作为蛋白质和生物材料之间界面的研究。这些包括对蛋白质的抵抗机制、拒绝蛋白质的聚电解质多层膜以及亲水性、多糖和磷脂性质的涂层。获得抗粘附表面所需的机制包括空间排斥、与水相关的效应和体积效应。此外，使用亲水性、高度水合、和电中性涂层已显示出良好的降低细胞粘附的能力。此外，在可用的方法中，逐层沉积的方法被称为操纵蛋白质和细胞粘附行为的有趣过程。