ABSTRACT

Objectives

Magnetic resonance (MR) R2 relaxometry is a safe, noninvasive diagnostic modality for the evaluation of iron levels in the contents of ovarian cysts. The study aims to investigate the sensitivity and specificity of the two methods, R2 value and iron level, in diagnosing OMA patients in the validation set.

Methods

A prospective cohort study was conducted from 2013 to 2019. We investigated how R2 value was affected by iron-related compounds, antioxidants and bioelements in the cysts.

Results

The sensitivity and specificity of CF iron-based diagnosis of OMA was 96.6% and 95.4%, respectively. The sensitivity and specificity for R2 value in diagnosing OMA were 86.2% and 70.7%, respectively. The outcomes of the two tests were highly correlated (r = 0.758; P <0.001). The R2 value was positively correlated with CF levels of iron-related compounds and antioxidants. The R2 value was affected not only by iron ions but also by calcium ions.

Conclusion

Preoperative MR relaxometry may provide a noninvasive alternative to CF iron test in diagnosing OMA. The presence of paramagnetic cations in the cyst may be associated with reduced specificity.

中文翻译：

---

磁共振弛豫R2值和囊液铁水平对卵巢子宫内膜异位症诊断的验证

摘要

目标

磁共振 (MR) R2 弛豫测量法是一种安全、无创的诊断方法，用于评估卵巢囊肿内容物中的铁水平。该研究旨在调查 R2 值和铁水平这两种方法在诊断验证集中的 OMA 患者中的敏感性和特异性。

方法

从 2013 年到 2019 年进行了一项前瞻性队列研究。我们研究了 R2 值如何受到包囊中铁相关化合物、抗氧化剂和生物元素的影响。

结果

CF铁基诊断OMA的敏感性和特异性分别为96.6%和95.4%。R2值诊断OMA的敏感性和特异性分别为86.2%和70.7%。两项测试的结果高度相关（r = 0.758；P <0.001）。R2 值与铁相关化合物和抗氧化剂的 CF 水平呈正相关。R2 值不仅受铁离子影响，还受钙离子影响。

结论

术前 MR 松弛测量法可以为诊断 OMA 提供 CF 铁测试的无创替代方法。囊肿中顺磁性阳离子的存在可能与特异性降低有关。