Introduction: Cross-reactivity between shrimp and house dust mite (HDM) proteins has been widely documented. In tropical region, shrimp (5–15%) and mite sensitization (80–95%) is prevalent in allergic patients. However, the clinical relevance of shrimp sensitization in patients with allergic rhinitis (AR) has been poorly studied. The aim of this study was to determine the prevalence and the clinical relevance shrimp IgE sensitization in AR patients sensitized to Dermatophagoides pteronyssinus. Methods: The study was conducted in Medellin (Colombia). A cross-sectional study in patients with AR sensitized to HDM was performed in 3 steps: (i) assessment of IgE sensitization frequency to shrimp Penaeus azteca, Litopenaeus vannamei, and tropomyosin homologous allergens rDer p 10, rPen a 1, and rLit v 1, (ii) evaluation of the clinical relevance of shrimp sensitization using oral challenge test (OCT) and (iii) identification of possible risk factors for positive-OCT results. Ethical committee approval was obtained. Results: From 443 patients with AR, 86 (19.4%) were sensitized to shrimp and 23 of them (26.7%) had shrimp allergy diagnosis. Thirty-six of the patients sensitized to shrimp (41.2%) reported not previously consumed this food and eleven of them had a positive-OCT (30.5%). There was not statistically significant difference in total IgE or sIgE (D. pteronyssinus, P. azteca, L. vannamei, rPen a 1, and rLit v 1) between OCT groups (positive vs. negative results). Anti-Der p 10 IgE was associated with risk for a positive-OCT in different multivariable scenarios. Discussion/Conclusion: Our results suggest that in patients with HDM-associated AR and shrimp IgE sensitization is necessary to evaluate the clinical relevance of shrimp IgE even if the patient has never consumed shrimp because of cross-reactivity. Anti-Der p 10 could be a possible biomarker of clinical relevance to shrimp sensitization and could reduce the need for OCTs.
Int Arch Allergy Immunol

中文翻译：

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过敏性鼻炎患者对虾致敏的临床相关性：作为预测因子的抗 Der p 10 IgE

简介：虾和屋尘螨 (HDM) 蛋白质之间的交叉反应性已被广泛记录。在热带地区，虾（5-15%）和螨致敏（80-95%）在过敏患者中普遍存在。然而，虾致敏对过敏性鼻炎 (AR) 患者的临床相关性研究很少。本研究的目的是确定对屋尘螨 过敏的 AR 患者中虾 IgE 致敏的患病率和临床相关性。方法：该研究在麦德林（哥伦比亚）进行。对 HDM 敏感的 AR 患者进行的横断面研究分 3 个步骤进行：(i) 评估 IgE 对阿兹台克对虾、南美白对虾、南美白对虾、和原肌球蛋白同源过敏原 rDer p 10、rPen a 1 和 rLit v 1，(ii) 使用口服激发试验 (OCT) 评估虾致敏的临床相关性，以及 (iii) 确定阳性 OCT 结果的可能风险因素。获得了伦理委员会的批准。结果：在 443 名 AR 患者中，86 名 (19.4%) 对虾过敏，其中 23 名 (26.7%) 被诊断为虾过敏。36 名对虾敏感的患者 (41.2%) 报告以前没有食用过这种食物，其中 11 名的 OCT 呈阳性 (30.5%)。总 IgE 或 sIgE ( D. pteronyssinus, P. azteca, L. vannamei、rPen a 1 和 rLit v 1) 在 OCT 组之间（阳性与阴性结果）。在不同的多变量情况下，抗-Der p 10 IgE 与 OCT 阳性的风险相关。讨论/结论：我们的结果表明，即使患者由于交叉反应从未食用过虾，也有必要对 HDM 相关 AR 和虾 IgE 致敏以评估虾 IgE 的临床相关性。Anti-Der p 10 可能是与虾致敏临床相关的生物标志物，并可以减少对 OCT 的需求。
Int Arch 过敏免疫