Centenarians experience successful ageing, although they still present high heterogeneity in their health status. The frailty index is a biomarker of biological age, able to capture such heterogeneity, even at extreme old age. At the same time, other biomarkers (e.g., epigenetic clocks) may be informative the biological age of the individual and potentially describe the ageing status in centenarians. In this article, we explore the relationship between epigenetic clocks and frailty index in a cohort of Italian centenarians. No association was reported, suggesting that these two approaches may describe different aspects of the same ageing process.

中文翻译：

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意大利半百岁老人的衰弱指数与表观遗传时钟之间没有关联

百岁老人经历了成功的老龄化，尽管他们的健康状况仍然存在高度异质性。虚弱指数是生物年龄的生物标志物，即使在极度老年时也能捕捉到这种异质性。同时，其他生物标志物（例如，表观遗传时钟）可能会为个体的生物学年龄提供信息，并可能描述百岁老人的衰老状态。在本文中，我们探讨了一组意大利百岁老人的表观遗传时钟与衰弱指数之间的关系。没有报告任何关联，这表明这两种方法可能描述了同一衰老过程的不同方面。