Cervicitis is predominantly caused by Neisseria gonorrhoeae and Chlamydia trachomatis, which accounts for almost half of all the cases of cervicitis. The role of newer organisms like Mycoplasma genitalium and Ureaplasma sp. and association of bacterial load with cervicitis are also not well established. So the study aimed to determine the relative frequency of these organisms and their load in association with cervicitis cases from north India. A case–control study involving 300 women was conducted using quantitative real-time PCR from endocervical swabs for identification of organisms and quantification of bacterial load. Among 150 cervicitis cases, C. trachomatis, N. gonorrhoeae, M. genitalium and Ureaplasma parvum were detected in 5 (3·3%), 10 (6·6%), 37(24·6%) and 47 (31·3%) respectively. Old age (<0·001, chi-squared test) and irregular menstrual cycles (<0·001, chi-squared test) were significantly associated with cervicitis. M genitalium was the only organism to be associated significantly with cervicitis with regard to age (<0·031) and symptoms like discharge (P < 0·033, chi-squared test) and dysuria (P < 0·044, chi-squared test) in multivariate analysis. Our finding suggests that the bacterial load of these organisms is not significantly associated with cervicitis. However, we found significant association of M. genitalium infection with clinical characteristics of cervicitis cases.

中文翻译：

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北印度人群中沙眼衣原体、淋病奈瑟菌、生殖支原体和脲原体感染和机体负荷与宫颈炎的关联

宫颈炎主要由引起奈瑟 淋球菌和沙眼衣原体，几乎占一半的宫颈炎的病例。新生物如生殖支原体和脲原体的作用。细菌负荷与宫颈炎的关系也没有得到很好的证实。因此，该研究旨在确定这些生物的相对频率及其与印度北部宫颈炎病例相关的负荷。一项涉及 300 名妇女的病例对照研究使用来自宫颈管拭子的定量实时 PCR 进行，以鉴定微生物并量化细菌负荷。在 150 例宫颈炎病例中，沙眼衣原体、淋病奈瑟菌、分别在5（3·3%）、10（6·6%）、37（24·6%）和47（31·3%）个中检测到生殖器支原体和小脲原体。高龄（<0·001，卡方检验）和月经周期不规则（<0·001，卡方检验）与宫颈炎显着相关。M genitalium是唯一在年龄 (<0·031) 和分泌物 ( P  < 0·033, 卡方检验) 和排尿困难 ( P  < 0·044, 卡方检验)等症状方面与宫颈炎显着相关的生物体检验）进行多变量分析。我们的发现表明，这些微生物的细菌负荷与宫颈炎没有显着相关性。然而，我们发现M. genitalium 的显着关联 感染具有宫颈炎临床特征的病例。