For more than 30 years, the association between the Hawaiian bobtail squid, Euprymna scolopes, and the bioluminescent bacterium Vibrio fischeri has been studied as a model system for understanding the colonization of animal epithelia by symbiotic bacteria. The squid–vibrio light-organ system provides the exquisite resolution only possible with the study of a binary partnership. The impact of this relationship on the partners’ biology has been broadly characterized, including their ecology and evolutionary biology as well as the underlying molecular mechanisms of symbiotic dynamics. Much has been learned about the factors that foster initial light-organ colonization, and more recently about the maturation and long-term maintenance of the association. This Review synthesizes the results of recent research on the light-organ association and also describes the development of new horizons for E. scolopes as a model organism that promises to inform biology and biomedicine about the basic nature of host–microorganism interactions.

30 多年来，夏威夷短尾鱿鱼、Euprymna scolopes和生物发光细菌Vibrio fischeri之间的联系已被研究作为了解共生细菌在动物上皮细胞中定植的模型系统。鱿鱼-弧菌光器官系统提供了只有通过研究二元伙伴关系才有可能实现的精细分辨率。这种关系对合作伙伴生物学的影响已被广泛描述，包括他们的生态学和进化生物学以及共生动力学的潜在分子机制。关于促进最初的光器官定植的因素，以及最近关于该关联的成熟和长期维持的因素，已经了解了很多。本综述综合了最近关于光器官关联的研究结果，并描述了E. scolopes新视野的发展作为一种模式生物，它有望为生物学和生物医学提供有关宿主-微生物相互作用的基本性质的信息。