Transmural healing is associated with substantial improvements in disease-related outcomes for patients with Crohn's disease, but there is no single validated definition of transmural healing to date. We did a systematic review to summarise the available definitions and to evaluate the effect of transmural healing on disease-related outcomes for patients with Crohn's disease by searching PubMed, Cochrane Library, and Web of Science for interventional and non-interventional studies. Seventeen studies were included, reporting rates of transmural healing in between 14·0% and 42·4% of patients. Transmural healing was assessed with magnetic resonance enterography, bowel sonography, or CT enterography. Most studies used bowel wall thickness, with 3 mm or less as the most frequent cutoff, to define transmural healing. Vascularisation assessed by doppler ultrasound and absence of complications or contrast enhancement were also used for this definition. Transmural healing was significantly associated with improvements in disease-related outcomes. In addition, there was a good correlation between transmural healing, mucosal healing, and selected biomarkers. We conclude that bowel wall thickness is the most frequently used item to evaluate transmural healing, which is associated with improvements in long-term outcomes of Crohn's disease and should be considered as a new treatment target.

透壁愈合与克罗恩病患者疾病相关结果的显着改善有关，但迄今为止还没有单一的透壁愈合定义。我们通过在 PubMed、Cochrane 图书馆和 Web of Science 中搜索介入性和非介入性研究，进行了系统评价，以总结可用的定义并评估透壁愈合对克罗恩病患者疾病相关结果的影响。包括 17 项研究，报告的透壁愈合率在 14·0% 到 42·4% 的患者之间。通过磁共振小肠造影、肠超声检查或 CT 小肠造影评估透壁愈合。大多数研究使用肠壁厚度，以 3 mm 或更少作为最常见的截止值，来定义透壁愈合。通过多普勒超声评估的血管化以及没有并发症或对比增强也用于此定义。透壁愈合与疾病相关结果的改善显着相关。此外，透壁愈合、粘膜愈合和选定的生物标志物之间存在良好的相关性。我们得出结论，肠壁厚度是评估透壁愈合最常用的项目，这与克罗恩病长期预后的改善有关，应被视为新的治疗目标。粘膜愈合和选定的生物标志物。我们得出结论，肠壁厚度是评估透壁愈合最常用的项目，这与克罗恩病长期预后的改善有关，应被视为新的治疗目标。粘膜愈合和选定的生物标志物。我们得出结论，肠壁厚度是评估透壁愈合最常用的项目，这与克罗恩病长期预后的改善有关，应被视为新的治疗目标。