Microsampling: A role to play in Covid-19 diagnosis, surveillance, treatment and clinical trials,Drug Testing and Analysis

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Microsampling: A role to play in Covid-19 diagnosis, surveillance, treatment and clinical trials
Drug Testing and Analysis ( IF 2.6 ) Pub Date : 2021-06-05 , DOI: 10.1002/dta.3107
Madhura Rajadhyaksha _{1,

2} , Vaishali Londhe ₁

Affiliation

The outbreak of the new coronavirus disease changed the world upside down. Every day, millions of people were subjected to diagnostic testing for Covid-19, all over the world. Molecular tests helped in the diagnosis of current infection by detecting the presence of viral genome whereas serological tests helped in detecting the presence of antibody in blood as well as contributed to vaccine development. This testing helped in understanding the immunogenicity, community prevalence, geographical spread and conditions post-infection. However, with the contagious nature of the virus, biological specimen sampling involved the risk of transmission and spread of infection. Clinic or pathology visit was the most concerning part. Trained personnel and resources was another barrier. In this scenario, microsampling played an important role due to its most important advantage of remote, contactless, small volume and self-sampling. Minimum requirements for sample storage and ease of shipment added value in this situation. The highly sensitive instruments and validated assay formats assured the accuracy of results and stability of samples. Microsampling techniques are contributing effectively to the Covid-19 pandemic by reducing the demand for clinical staff in population-level testing. The validated and established applications supported the use of microsampling in diagnosis, therapeutic drug monitoring, development of treatment or vaccines and clinical trials for Covid-19.

中文翻译：

微量采样：在 Covid-19 诊断、监测、治疗和临床试验中发挥的作用

新型冠状病毒病的爆发使世界发生了天翻地覆的变化。每天，全世界有数百万人接受 Covid-19 的诊断测试。分子检测通过检测病毒基因组的存在有助于诊断当前感染，而血清学检测有助于检测血液中抗体的存在并有助于疫苗开发。该测试有助于了解免疫原性、社区流行率、地理传播和感染后的状况。然而，由于病毒具有传染性，生物样本取样存在传播和传播感染的风险。诊所或病理访问是最令人关注的部分。训练有素的人员和资源是另一个障碍。在这种情况下，微采样因其远程、非接触、小体积和自采样的最重要优势而发挥了重要作用。在这种情况下，样品存储和运输便利性的最低要求增加了价值。高度灵敏的仪器和经过验证的分析形式确保了结果的准确性和样品的稳定性。微采样技术通过减少人群水平测试对临床工作人员的需求，有效地促进了 Covid-19 大流行。经验证和建立的应用程序支持在 Covid-19 的诊断、治疗药物监测、治疗或疫苗的开发和临床试验中使用微采样。高度灵敏的仪器和经过验证的分析形式确保了结果的准确性和样品的稳定性。微采样技术通过减少人群水平测试对临床工作人员的需求，有效地促进了 Covid-19 大流行。经过验证和建立的应用程序支持在 Covid-19 的诊断、治疗药物监测、治疗或疫苗的开发和临床试验中使用微采样。高度灵敏的仪器和经过验证的分析形式确保了结果的准确性和样品的稳定性。微采样技术通过减少人群水平测试对临床工作人员的需求，有效地促进了 Covid-19 大流行。经过验证和建立的应用程序支持在 Covid-19 的诊断、治疗药物监测、治疗或疫苗的开发和临床试验中使用微采样。

更新日期：2021-07-20

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