The search for relatively safe pesticides to control pests continues to reduce the damage they cause and avoid the negative effects of pesticides on the environment. The red palm weevil (RPW), Rhynchophorus ferrugineus, is the most dangerous pest on palm trees of all kinds, especially in arid areas. Ivermectin (IVM), an analog of abamectin, shows physiological efficacy against insects at very low concentrations. This study was performed to evaluate the biochemical and histopathological effects of sublethal concentrations of IVM on cells of the testes and ovaries of R. ferrugineus. Mortality resulting from feeding IVM at concentrations of 2, 1, 0.5 0.25, 0.125 and 0.0625 ppm was estimated. The LC50 was calculated as 0.685 ppm for males and 1.23 ppm for females. Feeding the males and females at sublethal concentrations of 0.0625 ppm (LC15 for females, LC21 for males), 0.125 ppm (LC21 for females, LC28 for males) and 0.25 ppm (LC29 for females, LC37 for males) resulted in IVM concentration-dependent decreases in the activity of acetylcholinesterase and catalase and the content of glutathione accompanied by an increase in malondialdehyde. The histopathological effects of IVM concentrations of 0.25, 1 and 2 ppm indicate that IVM induced apoptosis in subcellular organelles of the testis and ovary. In conclusion, the results of this study revealed that sublethal IVM at 0.0625 ppm or higher induced reproductive toxicity in the RPW via redox disruptions and apoptotic cell death.

寻找相对安全的农药来控制害虫，不断减少它们造成的损害，避免农药对环境的负面影响。红棕榈象鼻虫 (RPW) Rhynchophorus ferrugineus是各种棕榈树上最危险的害虫，尤其是在干旱地区。伊维菌素 (IVM) 是阿维菌素的一种类似物，在非常低的浓度下显示出对昆虫的生理功效。进行这项研究是为了评估亚致死浓度的 IVM 对R. ferrugineus睾丸和卵巢细胞的生化和组织病理学影响. 估计因喂食浓度为 2、1、0.5、0.25、0.125 和 0.0625 ppm 的 IVM 导致的死亡率。LC50 计算为男性为 0.685 ppm，女性为 1.23 ppm。以 0.0625 ppm（雌性 LC15，雄性 LC21）、0.125 ppm（雌性 LC21，雄性 LC28）和 0.25 ppm（雌性 LC29，雄性 LC37）的亚致死浓度喂养雄性和雌性导致 IVM 浓度依赖性乙酰胆碱酯酶和过氧化氢酶活性降低，谷胱甘肽含量降低，同时丙二醛增加。IVM 浓度为 0.25、1 和 2 ppm 的组织病理学效应表明，IVM 在睾丸和卵巢的亚细胞器中诱导细胞凋亡。总之，这项研究的结果表明，亚致死 IVM 在 0.