Introduction: The aim of this case was to investigate the association of the Zika virus infection in utero with the autism spectrum disorder (ASD) as clinical outcome that presented no congenital anomalies. Methods: ASD was diagnosed in the second year of life by different child neurologists and confirmed by DSM-5 and ASQ. After that, an extensive clinical, epidemiological, and genetic evaluations were performed, with main known ASD causes ruled out. Results: An extensive laboratorial search was done, with normal findings. SNP array identified no pathogenic variants. Normal neuroimaging and EEG findings were also obtained. ZIKV (Zika virus) IgG was positive, while IgM was negative. Other congenital infections were negative. The exome sequencing did not reveal any pathogenic variant in genes related to ASD. Conclusion: Accordingly, this report firstly associates ZIKV exposure to ASD.
Neuroimmunomodulation

中文翻译：

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与自闭症谱系障碍相关的寨卡病毒感染：病例报告

简介：本病例的目的是调查子宫内寨卡病毒感染与自闭症谱系障碍 (ASD) 的关联，作为临床结果，没有先天性异常。方法： ASD 在出生后第二年由不同的儿童神经科医生诊断，并通过 DSM-5 和 ASQ 确认。之后，进行了广泛的临床、流行病学和遗传评估，排除了已知的主要 ASD 原因。结果：进行了广泛的实验室搜索，结果正常。SNP 阵列未发现致病变异。还获得了正常的神经影像学和脑电图结果。ZIKV（寨卡病毒）IgG 为阳性，而 IgM 为阴性。其他先天性感染呈阴性。外显子组测序未发现与 ASD 相关的基因中的任何致病变异。结论：因此，本报告首先将 ZIKV 暴露与 ASD 联系起来。
神经免疫调节