Atrophied T2 lesion volume (LV), reflecting the complete transformation of lesions into cerebrospinal fluid (CSF), has been associated with disease progression in multiple sclerosis (MS). The underlying damage leading to lesion destruction remains poorly understood. The objective of this study was to use diffusion tensor imaging (DTI) to investigate the extent of microstructural tissue damage at baseline in lesions that subsequently transform into CSF.

中文翻译：

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弥散张量成像显示多发性硬化症中病变组织有更大的微观结构损伤，这些组织会收缩成脑脊液

萎缩的 T2 病灶体积 (LV)，反映病灶完全转化为脑脊液 (CSF)，与多发性硬化症 (MS) 的疾病进展有关。导致病变破坏的潜在损害仍然知之甚少。本研究的目的是使用弥散张量成像 (DTI) 来研究随后转化为脑脊液的病变基线时的微结构组织损伤程度。