Radiation inactivation of enveloped viruses occurs as the result of damages at the molecular level of their genome. The rapidly emerging and ongoing coronavirus disease 2019 (COVID-19) pneumonia pandemic prompted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global health crisis and an economic devastation. The readiness of an active and safe vaccine against the COVID-19 has become a race against time in this unqualified global panic caused by this pandemic. In this review, which we hope will be helpful in the current situation of COVID-19, we analyze the potential use of γ-irradiation to inactivate this virus by damaging at the molecular level its genetic material. This inactivation is a vital step towards the design and development of an urgently needed, effective vaccine against this disease.

中文翻译：

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伽马射线照射介导的包膜病毒灭活并保持基因组完整性：在 SARS-CoV-2 灭活疫苗开发中的潜在应用

有包膜病毒的辐射灭活是其基因组分子水平受损的结果。由严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 引发的迅速出现且持续存在的 2019 冠状病毒病 (COVID-19) 肺炎大流行现已成为一场全球健康危机和经济灾难。在这场大流行引发的全球恐慌中，准备好针对 COVID-19 的主动且安全的疫苗已成为一场与时间的赛跑。在这篇综述中，我们分析了 γ 辐射通过在分子水平上破坏其遗传物质来灭活该病毒的潜在用途，希望对当前的 COVID-19 情况有所帮助。这种灭活是设计和开发针对这种疾病的迫切需要的有效疫苗的重要一步。