Along with the rapid development of nanotechnology, the biosafety assessment of nanotechnology products, including nanomaterials (NMs), has become more and more important. The nematode Caenorhabditis elegans is a valuable model organism that has been widely used in the field of biology because of its excellent advantages, including low cost, small size, short life span, and highly conservative genomes with vertebral animals. In recent years, the number of nanotoxicological researchers using C. elegans has been growing. According to these available studies, the present review classified the adverse effects of NMs in C. elegans into systematic, cellular, and molecular toxicity, and focused on summarizing and analyzing the underlying mechanisms of metal, metal oxide, and nonmetallic NMs causing toxic effects in C. elegans. Our findings provide insights into what further studies are needed to assess the biosafety of NMs in the ecosystem using C. elegans. Environ Toxicol Chem 2021;40:2406–2424. © 2021 SETAC

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纳米材料对模型生物秀丽隐杆线虫的不利影响研究进展

随着纳米技术的快速发展，包括纳米材料（NMs）在内的纳米技术产品的生物安全性评估变得越来越重要。线虫秀丽隐杆线虫是一种有价值的模式生物，因其成本低、体积小、寿命短、与脊椎动物基因组高度保守等优点而被广泛应用于生物学领域。近年来，使用秀丽隐杆线虫的纳米毒理学研究人员的数量一直在增长。根据这些现有研究，本综述将 NMs 对秀丽隐杆线虫的不利影响进行了分类。研究系统性、细胞性和分子毒性，重点总结和分析了金属、金属氧化物和非金属 NM 在秀丽隐杆线虫中引起毒性作用的潜在机制。我们的研究结果为使用秀丽隐杆线虫评估生态系统中 NM 的生物安全性需要哪些进一步研究提供了见解。环境毒物化学2021；40:2406–2424。© 2021 SETAC